Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pia Karina Nørregaard"'
Autor:
Cooper Martin, Pia Karina Nørregaard, Jean-Michel Linget, Emelie Bjurling, Jean-Marie Receveur, Peter Aadal Nielsen, Anthony Murray, Thomas Högberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:453-457
A series of amides, amidines and amidoximes have been made from the corresponding nitrile compounds, to provide potent antagonists and inverse agonists for the CB1 receptor with considerably lower lipophiliciy, higher polar surface area and improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1d4234d82a51c4fa6c2b46aad74f0e
https://doi.org/10.1016/j.bmcl.2009.12.003
https://doi.org/10.1016/j.bmcl.2009.12.003
Autor:
Milka Vrecl, Dorthe L.C. Almholt, Pia Karina Nørregaard, Azra Pogačnik, Anders Heding, Lisbeth Elster
Publikováno v:
SLAS Discovery. 14:371-380
CB1 receptor (CB1R) antagonists have been demonstrated to be effective in treating obesity and related disorders. This study has been focused on establishing a beta-arrestin 2-based screening assay for the CB1R using BRET2 technology. When the existi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c4d17e51016851abb13c8058650455
https://doi.org/10.1177/1087057109333101
https://doi.org/10.1177/1087057109333101
Autor:
Pia Karina Nørregaard, Emelie Bjurling, Peter Aadal Nielsen, Niklas Sköld, Thomas Högberg, Jean-Marie Receveur, Cooper Martin
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
A chemically diverse library of secondary and tertiary 4-cyanomethyl-1,5-diphenyl-1H-pyrazole-3-carboxamides was synthesized to enable mapping of the SAR, in the eastern amide region, with regard to CB1 antagonist activity, This study was initiated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b432d56574110059c62d46529168a6
https://pubmed.ncbi.nlm.nih.gov/19954978
https://pubmed.ncbi.nlm.nih.gov/19954978
Autor:
Thomas M. Frimurer, Jean-Marie Receveur, Trond Ulven, Thomas Högberg, Pia Karina Nørregaard, Øystein Rist, Paul Brian Little
Publikováno v:
Journal of medicinal chemistry. 48(18)
Novel 6-acylamino-2-aminoquinoline melanin-concentrating hormone 1 receptor (MCH1R) antagonists were identified by sequential in silico screening with 3D pharmacophore models derived from a series of benzamide antagonists. The structure-activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b229cfc4ba944f0080ac94b61abf74d
https://pubmed.ncbi.nlm.nih.gov/16134937
https://pubmed.ncbi.nlm.nih.gov/16134937
Autor:
Trond Ulven, Paul Brian Little, Jean-Marie Receveur, Thomas Frimruer, Øystein Rist, Pia Karina Nørregaard, Mathiesen, Jesper M., Thomas Högberg
Publikováno v:
University of Copenhagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4f29360bac4ad774480b0ed44815363d
https://curis.ku.dk/portal/en/publications/6acylamino2amino4methylquinolines-as-potent-melaninconcentrating-hormone-1-receptor-antagonists(e63ae480-2d01-45a8-a0af-7a8a4a8f51e4).html
https://curis.ku.dk/portal/en/publications/6acylamino2amino4methylquinolines-as-potent-melaninconcentrating-hormone-1-receptor-antagonists(e63ae480-2d01-45a8-a0af-7a8a4a8f51e4).html
