High-Resolution Analysis of Gene Copy Number Alterations in Human Prostate Cancer Using CGH on cDNA Microarrays: Impact of Copy Number on Gene Expression

Autor: Maija Wolf, Spyro Mousses, Sampsa Hautaniemi, Ritva Karhu, Pia Huusko, Minna Allinen, Abdel Elkahloun, Outi Monni, Yidong Chen, Anne Kallioniemi, Olli-P Kallioniemi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 3, Pp 240-247 (2004)

Identification of target genes for genetic rearrangements in prostate cancer and the impact of copy number changes on gene expression are currently not well understood. Here, we applied high-resolution comparative genomic hybridization (CGH) on cDNA

Externí odkaz: https://doaj.org/article/c3db72a623b54bb9a18aa4eeada48002

NMD Microarray Analysis for Rapid Genome-Wide Screen of Mutated Genes in Cancer

Autor: Sami Kilpinen, Pia Huusko, Spyro Mousses, Therese Sørlie, Olli Kallioniemi, Aslaug Aamodt Muggerud, Henrik Edgren, Maija Wolf

Publikováno v: Cellular Oncology, Vol 27, Iss 3, Pp 169-173 (2005)
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Wolf, M, Edgren, H, Muggerud, A, Kilpinen, S, Huusko, P, Sørlie, T, Mousses, S & Kallioniemi, O 2005, ' NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer ', Cellular Oncology, vol. 27, no. 3, pp. 169-173 . < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617499/# >

Gene mutations play a critical role in cancer development and progression, and their identification offers possibilities for accurate diagnostics and therapeutic targeting. Finding genes undergoing mutations is challenging and slow, even in the post-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b356af003acc9007e9f839b37d27647c
https://doaj.org/article/0f22c64c81d7405987e6ba768500a099

Exclusion of large deletions and other rearrangements in BRCA1 and BRCA2 in Finnish breast and ovarian cancer families

Autor: Marika Kujala, Kati Pääkkönen, Heli Nevanlinna, Robert Winqvist, Pia Huusko, Jaana Lahti-Domenici, Katrin Rapakko, Minna Allinen

Publikováno v: Cancer Genetics and Cytogenetics. 129:120-123

In the Finnish population, identified mutations in BRCA1 and BRCA2 account for a less than expected proportion of hereditary breast and ovarian cancer. All previous studies performed in our country have concentrated on finding germ-line mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b053af264a74c6e28ebf8b73657f0c57
https://doi.org/10.1016/s0165-4608(01)00437-x

Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer

Autor: Antti Kauppila, Robert Winqvist, Risto Bloigu, Veli-Matti Kosma, Virpi Launonen, Seppo Saarikoski, Maarit Anttila, Arto Mannermaa, Pia Huusko, Frej Stenbäck, Ulla Puistola

Publikováno v: Cancer Genetics and Cytogenetics. 122:49-54

Tumor specimens from 78 epithelial ovarian cancer patients were examined for loss of heterozygosity (LOH) at 11 microsatellite markers at chromosomes 3p14.2, 6q27, 8p12, 11p15.5, 11q23.1-q24, 16q24.3, and 17p13.1, to evaluate the involvement, possibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b43629077caad3f34e9ee13ad957c86
https://doi.org/10.1016/s0165-4608(00)00279-x

Germ-Line TP53 Mutations in Finnish Cancer Families Exhibiting Features of the Li-Fraumeni Syndrome and Negative for BRCA1 and BRCA2

Autor: Kati Pääkkönen, Virpi Launonen, Jaakko Leisti, Robert Winqvist, Pia Huusko, Katariina Castrén, Ylermi Soini, K Vähäkangas

Publikováno v: Cancer Genetics and Cytogenetics. 112:9-14

Mutations in BRCA1 and BRCA2 account for a large portion of the inherited predisposition to breast and ovarian cancer. It was recently discovered that mutations in these two genes are less common in the Finnish population than expected. Because the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51af14e31eb1589a8500bd837bcbfaf
https://doi.org/10.1016/s0165-4608(98)00258-1