Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pia Cwarzko Rummel"'
Autor:
Pia Cwarzko Rummel, Mette M. Rosenkilde, Sahar Mirsharghi, Trond Ulven, Stefanie Thiele, Andreas Ritzen, Trine P Petersen
Publikováno v:
Petersen, T P, Mirsharghi, S, Rummel, P C, Thiele, S, Rosenkilde, M M, Ritzén, A & Ulven, T 2013, ' Multistep continuous-flow synthesis in medicinal chemistry : discovery and preliminary structure-activity relationships of CCR8 ligands ', Chemistry: A European Journal, vol. 19, no. 28, pp. 9343-9350 . https://doi.org/10.1002/chem.201204350
A three-step continuous-flow synthesis system and its application to the assembly of a new series of chemo- kine receptor ligands directly from commercial building blocks is reported. No scavenger columns or solvent switches are necessary to recover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54188f329a3f5c7cd3279844759e3b32
https://doi.org/10.1002/chem.201204350
https://doi.org/10.1002/chem.201204350
Autor:
Olav Larsen, Thomas M. Frimurer, Pia Cwarzko Rummel, Viktorija Daugvilaite, Michael Lückmann, Anders H. Johnsen, Mette M. Rosenkilde, Stefanie Karlshøj, Heidi Pihl, Line Barington
Chemokine receptors play important roles in the immune system and are linked to several human diseases. The initial contact of chemokines with their receptors depends on highly specified extracellular receptor features. Here we investigate the import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500574e42d9ea4ec22d839c16a57b016
https://europepmc.org/articles/PMC4965569/
https://europepmc.org/articles/PMC4965569/
Autor:
Tracy J. Jenkins, Pia Cwarzko Rummel, Stefanie Thiele, Mette M. Rosenkilde, Lars Baumann, Hans R. Lüttichau, Roland Kolbeck, Kristine Niss Arfelt, Anders H. Johnsen, Shomir Ghosh, James E. Pease
Publikováno v:
British Journal of Pharmacology. 167:1206-1217
Background and purpose Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::511ae76f2d7187efd9311825e7dc388e
https://doi.org/10.1111/j.1476-5381.2012.02076.x
https://doi.org/10.1111/j.1476-5381.2012.02076.x
Autor:
Mads Corvinius Nielsen, Mette M. Rosenkilde, Trond Ulven, Jens Engel-Andreasen, David E. Gloriam, Pia Cwarzko Rummel, Mikkel Malmgaard-Clausen, Stefanie Thiele, Anne Steen, Thomas M. Frimurer
Publikováno v:
Thiele, S, Malmgaard-Clausen, M, Engel-Andreasen, J, Steen, A K, Rummel, P C, Nielsen, M C, Gloriam, D E, Frimurer, T, Ulven, T & Rosenkilde, M M 2012, ' Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors ', Journal of Medicinal Chemistry, vol. 55, no. 18, pp. 8164-77 . https://doi.org/10.1021/jm301121j
Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2'-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 μM). Besides being agonists, they acted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db58b7e8e5c4212cbf00a8217ea5f0d
https://doi.org/10.1021/jm301121j
https://doi.org/10.1021/jm301121j
Autor:
Pia Cwarzko Rummel, Mette M. Rosenkilde, Laerke Smidt Hansen, Stefanie Thiele, Alexander Hovard Sparre-Ulrich, Trine P Petersen, Trond Ulven
Publikováno v:
Rummel, P C, Thiele, S, Hansen, L S, Petersen, T P, Sparre-Ulrich, A H, Ulven, T & Rosenkilde, M M 2013, ' Extracellular Disulfide Bridges Serve Different Purposes in Two Homologous Chemokine Receptors, CCR1 and CCR5 ', Molecular Pharmacology, vol. 84, no. 3, pp. 335-345 . https://doi.org/10.1124/mol.113.086702
In addition to the 7 transmembrane receptor (7TM)-conserved disulfide bridge between transmembrane (TM) helix 3 and extracellular loop (ECL)-2, chemokine receptors (CCR) contain a disulfide bridge between the N terminus and what previously was believ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8d80f86e55158bc11addfa63784a2c
https://portal.findresearcher.sdu.dk/da/publications/03d964bc-dde4-497e-8d80-aded6d39bf6d
https://portal.findresearcher.sdu.dk/da/publications/03d964bc-dde4-497e-8d80-aded6d39bf6d
Autor:
Pia Cwarzko Rummel, Stefanie Karlshøj, Anne Marie Førrisdahl Steen, Amy Elder, Roland Kolbech, Shomir Ghosh, Thomas Frimruer, Mette Marie Rosenkilde
Publikováno v:
University of Copenhagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::53604b86f4f6bfb1779ca083a10a08d7
https://curis.ku.dk/portal/en/publications/reversed-binding-of-a-small-molecule-ligand-in-homologous-chemokine-receptors--differential-role-of-extracellular-loop-2(2d645262-8004-446c-acac-2a93ab74d994).html
https://curis.ku.dk/portal/en/publications/reversed-binding-of-a-small-molecule-ligand-in-homologous-chemokine-receptors--differential-role-of-extracellular-loop-2(2d645262-8004-446c-acac-2a93ab74d994).html