Identification of a conserved chemokine receptor motif that enables ligand discrimination

Autor: Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette M. Rosenkilde

Publikováno v: Larsen, O, van der Velden, W J C, Mavri, M, Schuermans, S, Rummel, P C, Karlshøj, S, Gustavsson, M, Proost, P, Våbenø, J & Rosenkilde, M M 2022, ' Identification of a conserved chemokine receptor motif that enables ligand discrimination ', Science Signaling, vol. 15, no. 724, eabg7042 . https://doi.org/10.1126/scisignal.abg7042
Science signaling, vol. 15, no. 724, eabg7042, 2022.

Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserve

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https://curis.ku.dk/portal/da/publications/identification-of-a-conserved-chemokine-receptor-motif-that-enables-ligand-discrimination(29f6fc1f-9d65-409d-be3b-655cb9461521).html