GESTATIONAL EXPOSURE TO CHLORPYRIFOS AND APOE GENOTYPE INFLUENCE DEVELOPMENT AND ANXIETY BEHAVIOR: A COMPARISON WITH THE VALPROIC ANIMAL MODEL OF AUTISM

Autor: Judit Biosca Brull, Pia Basaure, Laia Guardia-Escote, Maria Cabré, Jordi Blanco, Miguel Morales-Navas, Fernando Sánchez-Santed, José Domingo, Maria Colomina

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S78-S79 (2023)

Externí odkaz: https://doaj.org/article/19a2b14f059a4df29f1159ac370d75eb

Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner

Autor: Fernando Sánchez-Santed, José L. Domingo, Cristian Pérez-Fernández, Maria Teresa Colomina, Maria Cabré, Laia Guardia-Escote, Jordi Blanco, Pia Basaure

Publikováno v: Food and Chemical Toxicology. 122:1-10

Organophosphorus pesticides – and in particular chlorpyrifos (CPF) – are extensively used worldwide. They mainly exert their toxicity by targeting the cholinergic system. Several studies suggested that the gene coding for apolipoprotein E (apoE),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23e05e552c556dfddeab711543559ee
https://doi.org/10.1016/j.fct.2018.09.069

New mechanistic insights on the metabolic-disruptor role of chlorpyrifos in apoE mice: a focus on insulin- and leptin-signalling pathways

Autor: Maria Cabré, Laia Guardia-Escote, Maria Teresa Colomina, José L. Domingo, Fiona Peris-Sampedro, Pia Basaure, Jordi Blanco, Domènec J. Sánchez

Publikováno v: Archives of Toxicology. 92:1717-1728

Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet. The ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cadacdbbc0a9d6b13fbdd97c6700d0
https://doi.org/10.1007/s00204-018-2174-3

Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet

Autor: Torsten Plösch, Cristian Pérez-Fernández, José L. Domingo, Jordi Blanco, Maria Cabré, Fernando Sánchez-Santed, Fiona Peris-Sampedro, Rikst Nynke Verkaik-Schakel, Pia Basaure, Judit Biosca-Brull, Laia Guardia-Escote, Maria Teresa Colomina

Publikováno v: riUAL. Repositorio Institucional de la Universidad de Almería
Universidad de Almería
International Journal of Environmental Research and Public Health, Vol 18, Iss 184, p 184 (2021)
International Journal of Environmental Research and Public Health, 18(1):184, 1-17. MDPI AG
International Journal of Environmental Research and Public Health
Volume 18
Issue 1

Developmental exposure to toxicants and diet can interact with an individual&rsquo
s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cd03fc4bfb43659259c7e86434fd2c
https://doi.org/10.3390/ijerph18010184

Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes

Autor: Maria Teresa Colomina, Pia Basaure, Domènec J. Sánchez, Maria Cabré, Miquel Mulero, Laia Guardia-Escote, Judit Biosca-Brull, Jordi Blanco, José L. Domingo

Publikováno v: Food and Chemical Toxicology. 137:111171

Chlorpyrifos (CPF) is an organophosphorus pesticide widely and extensively used in agriculture in more than one hundred countries and found ubiquitously in the environment. The present study was aimed at providing a better understanding of the obesog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7406ef5a7422f26ee4686d4ede903a0c
https://doi.org/10.1016/j.fct.2020.111171