The endothelial αENaC contributes to vascular endothelial function in vivo.

Autor: Antoine Tarjus, Martina Maase, Pia Jeggle, Ernesto Martinez-Martinez, Céline Fassot, Laurent Loufrani, Daniel Henrion, Pernille B L Hansen, Kristina Kusche-Vihrog, Frederic Jaisser

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185319 (2017)

The Epithelial Sodium Channel (ENaC) is a key player in renal sodium homeostasis. The expression of α β γ ENaC subunits has also been described in the endothelium and vascular smooth muscle, suggesting a role in vascular function. We recently demo

Externí odkaz: https://doaj.org/article/82ebd07e7f3743e494a55617ec486300

Cortical actin nanodynamics determines nitric oxide release in vascular endothelium.

Autor: Johannes Fels, Pia Jeggle, Kristina Kusche-Vihrog, Hans Oberleithner

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41520 (2012)

The release of the main vasodilator nitric oxide (NO) by the endothelial NO synthase (eNOS) is a hallmark of endothelial function. We aim at elucidating the underlying mechanism how eNOS activity depends on cortical stiffness (К(cortex)) of living e

Externí odkaz: https://doaj.org/article/36fc7a35d50943c4bcbf5e66c5ce99bb

The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer

Autor: Mariana R. Santesso, Flávia Mauad Levy, Ligia S. Antonio, J. Michael Edwardson, Rodrigo Cardoso de Oliveira, L J MacVinish, Pia Jeggle, Gavin E. Jarvis, Henry Miller, James Bartram, Marília Afonso Rabelo Buzalaf, Aline de Lima Leite

Publikováno v: Environmental Toxicology. 32:1455-1467

High concentrations of fluoride in the body may cause toxic effects. Here, we investigated the effects of fluoride on the structure, function, and proteome of a cortical collecting duct epithelium in vitro. Kidney tubule cells (M-1) were chosen becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2b44ecd0caf85a0bdc23e9b6884ff20
https://doi.org/10.1002/tox.22338

The cytotoxic effect of TiF4 and NaF on fibroblasts is influenced by the experimental model, fluoride concentration and exposure time

Autor: Rodrigo Cardoso de Oliveira, Pia Jeggle, John Michael Edwardson, Ana Carolina Magalhães, Luana Polioni Al-Ahj, Kellen Cristina da Silva Gasque, Marília Afonso Rabelo Buzalaf, Priscila Maria Aranda Salomão, Flávia Amadeu de Oliveira, Paula Danielle Rodrigues

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0179471 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objective Titanium tetrafluoride (TiF4) has shown promising effect in preventing tooth lesions. Therefore, we compared the cytotoxicity of TiF4 with sodium fluoride (NaF) (already applied in Dentistry) considering different fluoride concentrations, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2b2cc719ca508ee44783a5841d074
http://europepmc.org/articles/PMC5470716

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

Autor: R. Bryan Sutton, Xiaochu Lou, J. Michael Edwardson, Edwin R. Chapman, Zixuan He, Chantell S. Evans, Hua Bai, Pia Jeggle

Publikováno v: Molecular Biology of the Cell

Synaptotagmin (syt)-1 is a Ca2+ sensor that triggers rapid synaptic vesicle exocytosis. Mutations that disrupt physical interactions between the tandem Ca2+-sensing modules (C2 domains) of syt-1 disrupt regulated membrane fusion in reconstituted fusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896226394981fb59b62e5e0637b78d88
https://www.repository.cam.ac.uk/handle/1810/255059