Corrigendum: Patients with myeloproliferative neoplasms harbor high frequencies of CD8 T cell-platelet aggregates associated with T cell suppression

Autor: Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per thor Straten

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/593b961b919e482caa28a6ae47f86f5f

Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

Autor: Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Claus Desler

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation. Dihydroorotate dehydrogenase (DHODH) i

Externí odkaz: https://doaj.org/article/d07890576b8949e18e9b8caa7c3ef5cf

764 Expansion with IL-15 increases cytotoxicity of Vγ9Vδ2 T cells and is associated with higher levels of cytotoxic molecules and T-bet

Autor: Per thor Straten, Pia Aehnlich, Ana Micaela Carnaz Simoes, Signe Skadborg, Gitte Olofsson

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/274467db7f8442a194c5276a07c1b35b

Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8+ T Cells

Autor: Richard M. Powell, Marlies J. W. Peeters, Anne Rahbech, Pia Aehnlich, Tina Seremet, Per thor Straten

Publikováno v: Vaccines, Vol 9, Iss 11, p 1294 (2021)

There is an increasing interest in the development of Receptor Tyrosine Kinases inhibitors (RTKIs) for cancer treatment, as dysregulation of RTK expression can govern oncogenesis. Among the newer generations of RTKIs, many target Mer Tyrosine Kinase

Externí odkaz: https://doaj.org/article/ea4b29a1d4364e7390284cee2fd8917d

Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens

Autor: Özcan Met, Elfriede Noessner, Gitte Holmen Olofsson, Manja Idorn, Reno Debets, Ana Micaela Carnaz Simoes, Bernhard Moser, Pia Aehnlich, Per thor Straten, Signe Koggersbøl Skadborg

Publikováno v: Holmen Olofsson, G, Idorn, M, Carnaz Simões, A M, Aehnlich, P, Skadborg, S K, Noessner, E, Debets, R, Moser, B, Met, Ö & thor Straten, P 2021, ' Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens ', Frontiers in Immunology, vol. 12, 645131 . https://doi.org/10.3389/fimmu.2021.645131
Frontiers in Immunology
Frontiers in Immunology, 12:645131. Frontiers Media S.A.
Front. Immunol. 12:645131 (2021)
Frontiers in Immunology, Vol 12 (2021)

The human Vγ9Vδ2 T cell is a unique cell type that holds great potential in immunotherapy of cancer. In particular, the therapeutic potential of this cell type in adoptive cell therapy (ACT) has gained interest. In this regard optimization of in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eea1f87cb8d2f2265092ae0d2ee7848
https://doi.org/10.3389/fimmu.2021.645131