Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Pi-Xiao Wang"'
Autor:
Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang, Yi-Chao Zhao, Ke-Qiong Deng, Xi Jiang, Pi-Xiao Wang, Zan Huang, Hongliang Li
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitinat
Externí odkaz:
https://doaj.org/article/bf605e807c9540e797155442a3812052
Autor:
Pi-Xiao Wang, Xiao-Jing Zhang, Pengcheng Luo, Xi Jiang, Peng Zhang, Junhong Guo, Guang-Nian Zhao, Xueyong Zhu, Yan Zhang, Sijun Yang, Hongliang Li
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-22 (2016)
TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with th
Externí odkaz:
https://doaj.org/article/77626b712e6848859314d54a4402770d
Publikováno v:
Surgical Endoscopy. 37:1334-1341
Background Laparoscopic right posterior sectionectomy (LRPS) was technically challenging and lack of standardization. There were some approaches for LRPS, such as caudal approach and dorsal approach. During our practice, we initiated pure LRPS using
Autor:
Mei Xiang, Ping Ye, Yuanlin Zou, Feiyan Yang, Pi-Xiao Wang, Ling Zhu, Manhua Chen, Weijuan Li, Yi Zhou
Publikováno v:
Journal of molecular and cellular cardiology. 156
Pathological hypertrophy generally progresses to heart failure. Exploring effective and promising therapeutic targets might lead to progress in preventing its detrimental outcomes. Our current knowledge about lipopolysaccharide-induced tumor necrosis
Autor:
Li Zhang, Li-Jun Shen, Zhi-Gang She, Zan Huang, Xueyong Zhu, Chun Fang, Xiao-Dong Zhang, Pi-Xiao Wang, Yixing Qiu, Peng Zhang, Zhihua Wang, Song Tian, Jun Gong, Aibing Wang, Feng Li
Publikováno v:
Hepatology. 69:524-544
Tumor progression locus 2 (TPL2), a serine/threonine kinase, has been regarded as a potentially interesting target for the treatment of various diseases with an inflammatory component. However, the function of TPL2 in regulating hepatocyte metabolism
Autor:
Yi-Da Tang, Shimin An, Xia Yang, Siyuan Wang, Chun Fang, Jilin Zheng, Pi-Xiao Wang, Yan-Xiao Ji, Zhen-Zhen Yan, Zhi-Gang She, Li-Jun Shen, Rong Bao, Kuo Zhang, Feng-Juan Yan, Xueyong Zhu, Yu Qi, Song Tian
Publikováno v:
Hepatology. 67:1320-1338
Nonalcoholic fatty liver disease (NAFLD) is a prevalent and complex disease that confers a high risk of severe liver disorders. Despite such public and clinical health importance, very few effective therapies are currently available for NAFLD. We rep
Autor:
Ling-Ping Zhao, Xiaozhan Wang, Yan Zhang, Yong Wang, Yue-Xin Lu, Zhi-Xiang Huang, Pi-Xiao Wang, Peng Zhang, Xiao-Jing Zhang, Yan-Xiao Ji, Feng Li, Zhi-Gang She, Zan Huang, Xueyong Zhu, Zhao Huan, Jun Gong, Mao-Mao Gao, Song Tian, David E. Cohen, Hongliang Li, Michele Alves-Bezerra, Xia Yang, Lin Cai, Lan Bai
Publikováno v:
Nature Medicine. 24:213-223
Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis. The deubiquitinase c
Autor:
Yan-Xiao Ji, Feng Li, Xin Zhang, Xia Yang, Xin-Liang Ma, Song Tian, Peng Zhang, Zhi-Gang She, Ling-Ping Zhao, Zan Huang, Yan Zhang, Jun Gong, Mao-Mao Gao, Hongliang Li, Yue-Xin Lu, Xiao-Jing Zhang, Pi-Xiao Wang, Zhihua Wang, Chun Fang, Xueyong Zhu
Publikováno v:
Nature Medicine. 24:84-94
Activation of apoptosis signal-regulating kinase 1 (ASK1) in hepatocytes is a key process in the progression of nonalcoholic steatohepatitis (NASH) and a promising target for treatment of the condition. However, the mechanism underlying ASK1 activati
Autor:
Zhihua Wang, Peng Zhang, Jing Fang, Jun Gong, Xin Zhang, Pi-Xiao Wang, Xueyong Zhu, Qingguo Xie, Xiao-Jing Zhang, Miao Yin, Li-Jun Shen, Yan-Xiao Ji, Hongliang Li, Zhi-Gang She, Zan Huang, Jingjing Tong, Guang-Nian Zhao, Qiao-Fang Wei, Yutao Wang, Zhou Jiang, Yong Wang
Publikováno v:
Nature Medicine. 23:742-752
Non-alcoholic steatohepatitis (NASH) is an increasingly prevalent liver pathology that can progress from non-alcoholic fatty liver disease (NAFLD), and it is a leading cause of cirrhosis and hepatocellular carcinoma. There is currently no pharmacolog
Publikováno v:
Hypertension. 69:747-760
Innate immunity is the first line of host defense and is primarily initiated via the activation of germ line-encoded pattern-recognition receptor (PRR)–mediated innate immune signaling.1 Although many innate immune mechanisms have been identified,