Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Pi 3 kinase"'
Autor:
Satya P. Kunapuli, Carol Dangelmaier
Publikováno v:
Platelets
PI-3 Kinase plays an important role in platelet activation mainly through regulation of RASA3. Akt phosphorylation is an indicator for the activity of PI3 kinase. The aim of this study is to characterize the pathways leading to Akt phosphorylation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71bb5d42143e4c22155b12817a911ed
https://doi.org/10.1080/09537104.2020.1802415
https://doi.org/10.1080/09537104.2020.1802415
Publikováno v:
The FEBS Journal
The phosphoinositide 3-kinase (PI3K) family of lipid-modifying enzymes plays vital roles in cell signaling and membrane trafficking through the production of 3-phosphorylated phosphoinositides. Numerous studies have analyzed the structure and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343454c9e909af51354cfc0219ef3d71
https://pubmed.ncbi.nlm.nih.gov/33387369
https://pubmed.ncbi.nlm.nih.gov/33387369
Publikováno v:
Neuro Oncol
Virtually all primary glioblastomas have aberrant activation of the PI 3-kinase pathway through mutational inactivation of tumour suppressors such as PTEN and/or mutational activation of oncogenes. Most glioblastomas also overexpress the Rac guanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58fbf7fa7b1aff836443145562a44d2
https://europepmc.org/articles/PMC6847169/
https://europepmc.org/articles/PMC6847169/
Publikováno v:
European Heart Journal. 40
Rationale Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling in pulmonary arterioles. Increased activation of receptor tyrosine kinase (RTK)-mediated signaling pathways lead to increased proliferation and chemotaxis of pulm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6443e52e0134f89a48bc68bc215a9df
https://doi.org/10.1093/eurheartj/ehz748.0685
https://doi.org/10.1093/eurheartj/ehz748.0685
Autor:
Martin Mollenhauer, Stephan Baldus, Dennis Mehrkens, Eva Berghausen, Marius Vantler, M Zierden, Stephan Rosenkranz, Matti Adam
Publikováno v:
European Heart Journal. 40
Background The pathobiology of aortic aneurysms is characterized by vascular inflammation, extracellular matrix degeneration, and particularly by loss and dedifferentiation of vascular smooth muscle cells (SMCs). In SMCs, the PI 3-kinase isoform p110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2df8c39b9c253e5c7ecd9117a3a069
https://doi.org/10.1093/eurheartj/ehz748.0684
https://doi.org/10.1093/eurheartj/ehz748.0684
Autor:
Bhupal P. Bhetwal, Rajashree Thirumeni
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542c6f88286a9bef1f7e171ea6fd2562
https://doi.org/10.1096/fasebj.2020.34.s1.06053
https://doi.org/10.1096/fasebj.2020.34.s1.06053
Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma
Publikováno v:
Cancer Chemotherapy and Pharmacology. 75:595-608
SF1126 is a vascular-targeted pan-PI-3K inhibitor prodrug with antitumor and antiangiogenic activity and has completed phase I clinical trial in solid tumors and B-cell malignancies. In this study, we investigated the effect of SF1126 on hypoxic HIF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96befd2d0c52784b7a3f3d0470c51ae
https://doi.org/10.1007/s00280-014-2639-x
https://doi.org/10.1007/s00280-014-2639-x
Autor:
Kyung Sik Yoon, Insug Kang, Young Taek Oh, Ju Hie Lee, Joohun Ha, Hyung Hwan Baik, Wonchae Choe, Jung Yeon Lee, Sung-Soo Kim, Bong Sook Jhun
Publikováno v:
Neuroscience Letters. 712:134486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ed9dcaff8a8b81337a405327bd2cc3
https://doi.org/10.1016/j.neulet.2019.134486
https://doi.org/10.1016/j.neulet.2019.134486
Publikováno v:
Gastroenterology. 152:S12-S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60fdc63f0d68945f87b3489e7bfdc891
https://doi.org/10.1016/s0016-5085(17)30416-x
https://doi.org/10.1016/s0016-5085(17)30416-x