Výsledky vyhledávání - "Physiologie de la régulation"

A Topological Switch in the Cystic Fibrosis Transmembrane Conductance Regulator Modulates Channel Activity and Sensitivity to Disease-Causing Mutation

Autor: Rafael Colomer, David N. Sheppard, Jelle Hendrix, Els Pardon, Abel Garcia-Pino, Yiting Wang, Daniel Scholl, Chloe Martens, Marie Overtus, Toon Laeremans, Jan Steyaert, Maud Sigoillot, Cédric Govaerts

Publikováno v: Nature Chemical Biology

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is essential to maintain fluid homeostasis in key organs such as the lungs or the digestive systems. Functional impairment of CFTR due to mutation in the cftr gene lead to C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3173971a1993712b6d2fe6e6a2d37b
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326089

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Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells

Autor: Myrna Virreira, Nicolas Markadieu, Abdullah Sener, Philippe Golstein, Alain Boom, Raphaël Crutzen, Willy Malaisse, Vadim Shlyonsky, Renaud Beauwens

Publikováno v: Pflugers Archiv
Pflügers Archiv, 468 (4
Pflügers Archiv

Anions such as Cl− and HCO3 − are well known to play an important role in glucose-stimulated insulin secretion (GSIS). In this study, we demonstrate that glucose-induced Cl− efflux from β-cells is mediated by the Ca2+-activated Cl− channel a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e176e424d31934d0a02d5418a728620e
http://europepmc.org/articles/PMC4792454

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Dissertation/ Thesis

Rôle de l'oxygène dans les phénomènes de narcose à l'azote

Autor: Lafere, Pierre

Le plongeur subit de nombreuses contraintes issues du milieu dans lequel il évolue. La narcose à l’azote par ses effets sur la performance cognitiveen fait partie. Elle est impliquée dans de nombreux accidents de plongée sous-marine. Il est d

Externí odkaz: https://dipot.ulb.ac.be/dspace/bitstream/2013/304394/3/These_Lafere_final_second_depot.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/304394

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Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model

Autor: Mathieu Boxus, Julie Lodewick, Françoise Bex, Carla Sampaio, Lucas Willems, Anne-Sophie Rinaldi, Pierre P. Roger, Katia Coulonval

Publikováno v: Retrovirology, 10
Retrovirology

Transformation by the Tax oncoprotein of the human T cell leukemia virus type 1 (HTLV-1) is governed by actions on cellular regulatory signals, including modulation of specific cellular gene expression via activation of signaling pathways, accelerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee701f71482c8e8e3732ac7a311293e
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/149587

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Pulsed high oxygen induces a hypoxic-like response in Human Umbilical Endothelial Cells (HUVECs) and in humans

Autor: Peter Germonpré, Antonina Saija, Frauke Tillmans, David De Bels, Francesco Cimino, Costantino Balestra, Fabio Virgili, Antonio Speciale

Publikováno v: Journal of applied physiology (Bethesda, Md. 1985)

It has been proposed that relative changes of oxygen availability rather than steady state hypoxic or hyperoxic conditions, play an important role in HIF transcriptional effects. According to this hypothesis describing the "normobaric oxygen paradox"

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34278880dafefee0c49674208761cf5
https://hdl.handle.net/20.500.14017/eb073ff6-4f6f-432b-8672-fc9164fd9d42

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EPO and doping

Autor: Peter Germonpré, Costantino Balestra

Publikováno v: European Journal of Applied Physiology, 109 (5

Comment
Letter
info:eu-repo/semantics/published

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf0bd2e49d755471b7bb5322708ea89
https://doi.org/10.1007/s00421-010-1417-7

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CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

Autor: Xavier Bisteau, Ludger Hengst, Wim Declercq, Katia Coulonval, Pierre P. Roger, Bianca Colleoni, Sabine Paternot, Philippe De Groote, Karin Ecker

Publikováno v: PLOS genetics, 9 (5
PLoS Genetics
PLOS GENETICS
PLoS Genetics, Vol 9, Iss 5, p e1003546 (2013)

Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK). In animals, the only known CAK for CDK2 and CDK1 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a805b11b2fa196116ccce1ba880e312
https://doi.org/10.1371/journal.pgen.1003546

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Stimulation by thyrotropin and cyclic AMP of the proliferation of quiescent canine thyroid cells cultured in a defined medium containing insulin

Autor: Pierre P. Roger, Patricia Servais, Jacques Emile Dumont

Publikováno v: FEBS letters, 157 (2

We have developed serum-free primary cultures of differentiated follicular dog thyroid cells which allow the study of the hormonal control of cell proliferation. The cooperation of insulin and increasing cellular cyclic AMP by thyrotropin triggers th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22afb058ec7172b97dc8a78986012d21
https://pubmed.ncbi.nlm.nih.gov/6305722

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