Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Phyllissa Schmiedlin-Ren"'
Autor:
Ellen M. Zimmermann, David Shealy, Phyllissa Schmiedlin-Ren, Ahren C. Rittershaus, Ann Cai, Barbara J. McKenna, Josh S. Brudi, Laura J. Reingold, Kinan Rahal, Scott D. Swanson, Jeremy Adler
Publikováno v:
Inflammatory Bowel Diseases. 19:683-690
OBJECTIVE Treatment of Crohn's disease (CD) with anti-tumor necrosis factor α (TNFα) decreases intestinal inflammation, but the effect on fibrosis remains unclear. We hypothesized that treatment with rat-specific anti-TNFα will decrease the develo
Autor:
Phyllissa Schmiedlin-Ren, Gregory M. Christman, Ellen M. Zimmermann, Patricia Garcia, Jason S. Mathias, Huaijing Tang
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G326-G335
One of the most difficult and treatment-resistant complications of Crohn's disease is the development of fibrotic intestinal strictures due to mesenchymal cell hyperplasia and collagen deposition. Resveratrol, a phytoalexin found in berries, peanuts,
Publikováno v:
Molecular Pharmaceutics. 7:619-629
Understanding virus-cell interaction is a key to the design of successful gene delivery vectors. In the present study we investigated Ad5 transduction of enterocytes and M-cells utilizing differentiated Caco-2 cells and co-cultures of Caco-2 cells wi
Autor:
Jeremy Adler, Laura J. Reingold, Ahren C. Rittershaus, Ellen M. Zimmermann, Christopher S. Broxson, Scott R. Owens, Josh S. Brudi, Phyllissa Schmiedlin-Ren
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 311(4)
Anti-TNFα therapy decreases inflammation in Crohn's disease (CD). However, its ability to decrease fibrosis and alter the natural history of CD is not established. Anti-TNF-α prevents inflammation and fibrosis in the peptidoglycan-polysaccharide (P
Autor:
Phyllissa Schmiedlin-Ren, Kinan Rahal, Ahren C. Rittershaus, Jeremy Adler, Ellen M. Zimmermann, Laura J. Reingold, Scott R. Owens, Diane Bender
Publikováno v:
Inflammatory bowel diseases. 19(6)
The peptidoglycan-polysaccharide (PGPS) model using inbred rats closely mimics Crohn's disease. Our aim was to identify mouse strains that develop ileocolitis in response to bowel wall injection with PGPS. Mouse strains studied included NOD2 knockout
Autor:
Ellen M. Zimmermann, Christopher S. Broxson, Phyllissa Schmiedlin-Ren, Laura J. Reingold, Scott R. Owens
Publikováno v:
Gastroenterology. 150:S966
Autor:
Christopher P. Golembeski, Scott D. Swanson, Hero K. Hussain, Phyllissa Schmiedlin-Ren, Ellen M. Zimmermann, Trevor M. Verrot, Jeremy Adler, Barbara J. McKenna, Alexandros D. Polydorides, Peter D.R. Higgins
Publikováno v:
Radiology. 259(1)
To determine the utility of magnetization transfer (MT) in the identification and quantification of intestinal fibrosis in a rat model of Crohn disease.The university committee on the use and care of animals approved this study (UCUCA 08592). Lewis r
Autor:
Mita Ghosh, William O. Dobbins, Patricke E. Benedict, Phyllissa Schmiedlin-Ren, Paul B. Watkins, Joseph C. Kolars
Publikováno v:
Biochemical Pharmacology. 46:905-918
Enzymes within the CYP3A subfamily are major Phase I drug-metabolizing enzymes present in hepatocytes and small bowel enterocytes. These enzymes are highly inducible in the liver by many structurally diverse compounds, including a number of commonly
Publikováno v:
Journal of Clinical Investigation. 90:1871-1878
Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass" metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes are expressed in intestine, enterocyte RNA was hybridized on Norther
Autor:
Joseph C. Kolars, Phyllissa Schmiedlin-Ren, Paul B. Watkins, Bob D. Rush, Philip L. Stetson, John J. Voorhees, Mary J. Ruwart, Elizabeth A. Duell
Publikováno v:
Transplantation. 53:596-601
Cyclosporine is converted to its major metabolites (M-17, M-1, and M-21) in human liver by enzymes belonging to the P450IIIA subfamily. These enzymes are also present in rat and human enterocytes; however, the possibility that CsA is metabolized in e