Výsledky vyhledávání - "Phyllis Yerino"

In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450

Autor: Andrew Parkinson, Etsuko Usuki, Brian W. Ogilvie, Phyllis Yerino

Publikováno v: Drug-Drug Interactions ISBN: 9780429131967

Victims are those drugs whose clearance is predominantly determined by a single route of elimination, such as metabolism by a single cytochrome P450 (CYP) enzyme. This chapter focuses on in vitro reaction phenotyping and CYP inhibition. A wide range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::619c8ec61412d5171b542eaf065ff119
https://doi.org/10.1201/9780429131967-7

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An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides

Autor: David B. Buckley, Chase McCoy, Andrew Parkinson, Faraz Kazmi, Brian W. Ogilvie, Phyllis Yerino

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(8)

Oligonucleotides represent an expanding class of pharmacotherapeutics in development for various indications. Typically, oligonucleotides are developed with phosphorothioate linkages for the improvement of biologic stability; however, limited data ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b7a7f8b57c5df10d97bc57a0d5c78c
https://pubmed.ncbi.nlm.nih.gov/29735754

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A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement

Autor: Phyllis Yerino, Andrew Parkinson, Faraz Kazmi, Joanna E Barbara

Publikováno v: Drug Metabolism and Disposition. 43:523-533

Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd46798d29c130ab75c891bb10afccc
https://doi.org/10.1124/dmd.114.062620

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The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

Autor: Andrew Parkinson, Paul Toren, Brian W. Ogilvie, Phyllis Yerino, Amin Rostami-Hodjegan, Brandy L. Paris, David B. Buckley, Faraz Kazmi

Publikováno v: Drug Metabolism and Disposition. 39:2020-2033

As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but lansoprazole does not cause clinically significant inhibition of CYP2C19 whereas omeprazole does. To investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea4450da54ac6daf6ad7c7a691e98a
https://doi.org/10.1124/dmd.111.041293

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An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes

Autor: David B. Buckley, Brian W. Ogilvie, Phyllis Yerino, Jeff Holsapple, Brandy L. Paris, Andrew Parkinson, Paul Toren, Faraz Kazmi, Steve M. Otradovec

Publikováno v: Drug Metabolism and Disposition. 39:1370-1387

Metabolism-dependent inhibition (MDI) of cytochrome P450 is usually assessed in vitro by examining whether the inhibitory potency of a drug candidate increases after a 30-min incubation with human liver microsomes (HLMs). To augment the IC(50) shift,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1fab71bbfccfffb3aba39f25cb4257
https://doi.org/10.1124/dmd.111.038596

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System-Dependent Outcomes during the Evaluation of Drug Candidates as Inhibitors of Cytochrome P450 (CYP) and Uridine Diphosphate Glucuronosyltransferase (UGT) Enzymes: Human Hepatocytes versus Liver Microsomes versus Recombinant Enzymes

Autor: Faraz Kazmi, Brian W. Ogilvie, Phyllis Yerino, Brandy L. Paris, Andrew Parkinson, David B. Buckley

Publikováno v: Drug Metabolism and Pharmacokinetics. 25:16-27

The ability of a drug to cause clinically significant drug-drug interactions due to direct or metabolism-dependent inhibition of cytochrome P450 (CYP) can generally be predicted from in vitro studies with human liver microsomes (HLM) or recombinant C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69bc0a9f4987b64dcd3d0ae1d07356c
https://doi.org/10.2133/dmpk.25.16

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Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor

Autor: Andrew Parkinson, Joanna E Barbara, Phyllis Yerino, Faraz Kazmi

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 43(9)

Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae64e1890de38245b69669d07055bf93
https://pubmed.ncbi.nlm.nih.gov/26135009

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Comparative absorption of bismuth in Sprague-Dawley rats following oral administration of preparations containing bismuth sucrose octasulfate, bismuth subsalicylate, and bismuth subcitrate

Autor: Niranjan Rao, Paul W. Brown, Kin-Kai Hwang, Phyllis Yerino, Jim Chang

Publikováno v: Biopharmaceuticsdrug disposition. 18(1)

The absorption of bismuth from De-Nol (bismuth subcitrate, DN), Pepto-Bismol (bismuth subsalicylate, PB) and bismuth sucrose octasulfate (BISOS) was examined in male Sprague-Dawley rats after a single oral dose of each compound (60mg bismuth). Bismut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5476b4629de4e41e5253c322bc512f0
https://pubmed.ncbi.nlm.nih.gov/9008264

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Distribution and binding of the carcinogens 1-methyl-1-nitrosourea and 1-methyl-3-nitro-l-nitrosoguanidine in the guinea pig after oral administration

Autor: Paul V. Woolley, Seth D. Pinsky, Phyllis Yerino

Publikováno v: Carcinogenesis. 3:1443-1447

Guinea pigs were given radioisotopic 1-methyl-1-nitrosourea (MNU) or 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) as a single oral dose of 0.1 mmol/kg and uptake into TCA-precipitable material, whole tissue protein and 7-methyl-guanine and O6-methylgua

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https://doi.org/10.1093/carcin/3.12.1443

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