Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Phyllis R. Wachsberger"'
Autor:
Phyllis R. Wachsberger, Nicholas Feo, Adam P. Dicker, Barbara Rice, Benjamin E. Leiby, Yi Liu, Yaacov Richard Lawrence
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 140:573-582
Combined targeting with a PI3-kinase inhibitor, BKM120, and an Hsp90 inhibitor, HSP990, was investigated as a multi-targeted approach to potentiate cell death in glioblastoma (GBM). Additionally, the effect of dual drug treatment combined with cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4898d8f16a14449c11ffa2fcd64061d
https://doi.org/10.1007/s00432-014-1594-6
https://doi.org/10.1007/s00432-014-1594-6
PURPOSE: The tumor growth kinetics of the human LoVo colorectal xenograft model was assessed in response to vandetanib, an orally available receptor tyrosine kinase inhibitor, radiotherapy (RT), or irinotecan (CPT-11), as single therapies and in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d97a836dae180de24d47be023d0d96
https://ora.ox.ac.uk/objects/uuid:9ba73b3f-2929-4173-87dc-31e434a1baae
https://ora.ox.ac.uk/objects/uuid:9ba73b3f-2929-4173-87dc-31e434a1baae
Autor:
Phyllis R. Wachsberger, Yi Liu, Richard Yaacov Lawrence, Barbara Andersen, Adam P. Dicker, Xu Xia
Publikováno v:
Journal of Neuro-Oncology. 105:181-190
Glioblastomas (GBM) frequently overexpress the epidermal growth factor receptor (wtEGFR) or its mutant, EGFRvIII, contributing to chemo- and radioresistance. The current standard of care is surgery followed by radiation therapy with concurrent temozo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb40e9804be3c7202cedec232e553a2
https://doi.org/10.1007/s11060-011-0580-y
https://doi.org/10.1007/s11060-011-0580-y
Publikováno v:
Prostate Cancer and Prostatic Diseases. 8:127-132
Antiandrogen therapy is an important modality in the treatment of prostate cancer. Recent research into the role of angiogenesis in tumour growth and metastasis has uncovered links between antiandrogen therapy, radiation therapy and angiogenesis, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7beeaa24831f3e8331b199e70bb811b
https://doi.org/10.1038/sj.pcan.4500779
https://doi.org/10.1038/sj.pcan.4500779
Publikováno v:
Hematology/Oncology Clinics of North America. 18:1039-1057
Radiotherapy is one of the most widely used treatments for cancer; however, the development of tumor radioresistance is an ongoing problem. Agents that target tumor angiogenesis are being used in combination with radiotherapy to improve the therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5293584443030f1a7eff9b29739f977
https://doi.org/10.1016/j.hoc.2004.06.007
https://doi.org/10.1016/j.hoc.2004.06.007
Autor:
Phyllis R. Wachsberger, Miriam L. Wahl, David Berd, Dennis B. Leeper, C. W. Storck, J Reilly, Ronald A. Coss
Publikováno v:
International Journal of Hyperthermia. 20:93-106
Two human melanoma cell lines, SK-Mel-28 and DB-1, were used for in vitro studies of the mechanisms underlying heat resistance of human tumour cells adapted to growth in acidic environments. Adaptation to growth at low pH was characterized by resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6871cb73dbb254017fceb2b665e8b1
https://doi.org/10.1080/02656730310001605519
https://doi.org/10.1080/02656730310001605519
Autor:
Eric Gressen, Suzanne B. Bobyock, Phyllis R. Wachsberger, R A Coss, David Berd, C. W. Storck, A. Bhala, Dennis B. Leeper
Publikováno v:
Melanoma Research. 12:35-43
Melanoma exhibits heterogeneous growth patterns and widely varying sensitivities to multiple treatment modalities. This variability may reflect intrinsic genetic differences in factors giving rise to altered metabolism. Glucose is the primary energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86a88156439b57afbc9338357794bd2
https://doi.org/10.1097/00008390-200202000-00006
https://doi.org/10.1097/00008390-200202000-00006
Autor:
Phyllis R. Wachsberger, J.-S. Han, Miriam L. Wahl, C. W. Storck, Ronald A. Coss, David Berd, Dennis B. Leeper
Publikováno v:
International Journal of Hyperthermia. 18:404-415
Acute acidification is being investigated as a strategy to sensitize human melanoma to 42 degrees C hyperthermia. The present study was conducted to determine the effect of hyperthermia and acute extracellular acidification on the nuclear associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c329365aa5265bc7c098d542820e55
https://doi.org/10.1080/02656730210129745
https://doi.org/10.1080/02656730210129745
Publikováno v:
International Journal of Hyperthermia. 18:153-164
Betulinic acid is a known inducer of apoptosis in human melanoma that is most effective under conditions of low pH. It was hypothesized that betulinic acid, in combination with acute acidification and/or hyperthermia, would induce higher levels of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c9ef9abfdc6ed340fddff3b51966bf
https://doi.org/10.1080/02656730110091333
https://doi.org/10.1080/02656730110091333
Publikováno v:
International Journal of Hyperthermia. 18:216-232
CHO cells are normally sensitized to hyperthermia by acidic pH. However, CHO cells adapted to growth in pH 6.7 medium become less sensitive to heat killing at the reduced pH. The adapted cells maintain their ability to develop thermotolerance at pH 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5170bc59949c7999ddaa6d236f322d9c
https://doi.org/10.1080/02656730110119189
https://doi.org/10.1080/02656730110119189