Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Phyllis C, Leppert"'
Autor:
Md Soriful Islam, Sadia Afrin, Bhuchitra Singh, Friederike L. Jayes, Joshua T. Brennan, Mostafa A. Borahay, Phyllis C. Leppert, James H. Segars
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
Abstract Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP
Externí odkaz:
https://doaj.org/article/ec5c65d77a9d4bec9bd60d4bb10a2bae
Autor:
Ayman Al-Hendy, Andrea Tinelli, Quaker E. Harmon, James H. Segars, Emmanuel Paul, Elizabeth A. Stewart, Serdar E. Bulun, William H. Catherino, Daniel J. Tschumperlin, Phyllis C. Leppert, José A. Teixeira, Merrick T. Ducharme, Aymara Mas Perucho, Carlos Simón, Ami R. Zota, Darlene Dixon, Friederike L. Jayes, Donna D. Baird
Publikováno v:
F S Sci
Scientists from multiple basic disciplines and an international group of physician-scientists from the field of obstetrics and gynecology presented recent studies and discussed new and evolving theories of uterine fibroid etiology, growth and develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbb91559aa85fd20e9b6bf84f01baac
https://doi.org/10.1016/j.xfss.2020.11.001
https://doi.org/10.1016/j.xfss.2020.11.001
Publikováno v:
F1000Research, Vol 4 (2015)
Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occu
Externí odkaz:
https://doaj.org/article/39193b95a1ce4453ae5bdc8a9d59fe40
Autor:
Soriful Islam, James H. Segars, Joshua T. Brennan, Sadia Afrin, Mostafa A. Borahay, Friederike L. Jayes, Phyllis C. Leppert, Bhuchitra Singh
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine
Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c6209d5b53b5277493ec042e908fe5
https://doi.org/10.1002/ctm2.475
https://doi.org/10.1002/ctm2.475
Publikováno v:
Obstetrics and Gynecology International, Vol 2014 (2014)
The role of the extracellular matrix (ECM) and mechanotransduction as an important signaling factor in the human uterus is just beginning to be appreciated. The ECM is not only the substance that surrounds cells, but ECM stiffness will either compres
Externí odkaz:
https://doaj.org/article/ffa5b8691d8c4ef6ba57d5fe158ff41b
Publikováno v:
Seminars in Reproductive Medicine. 35:487-493
Fibroids (uterine leiomyomas) are the most common benign tumors of the female reproductive tract. Steroid hormones, growth factors, and cytokines have long been implicated in fibroid growth; however, research suggests that changes in the extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1abf5b39c547c52c9b5d9e6ae09c0ae
https://doi.org/10.1055/s-0037-1607268
https://doi.org/10.1055/s-0037-1607268
Autor:
Michael P. Diamond, Susan G. Silva, Sandra Ann Carson, Evan R. Myers, Peter G. McGovern, Christos Coutifaris, Bruce R. Carr, Michael P. Steinkampf, William D. Schlaff, Richard S. Legro, David S. Guzick, Donna L. Vogel, Phyllis C. Leppert
Publikováno v:
Fertility and sterility. 112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64156ae1b97b36685b41ece3e728b849
https://pubmed.ncbi.nlm.nih.gov/15533340
https://pubmed.ncbi.nlm.nih.gov/15533340
Autor:
Phyllis C. Leppert, David W. Schomberg, Liping Feng, Friederike L. Jayes, Lauren N.C. Johnson
Publikováno v:
Current Protein & Peptide Science. 18:155-166
Utilizing both primary myometrial cells and a myometrial cell line, we show here that myometrial cells undergo transition to a myofibroblast-like phenotype after a biological insult of 72 hours serum starvation and serum add-back (SB: 1% to 10% FBS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bece33663e37345f7eed3ecfb6c909
https://doi.org/10.2174/1389203717666160322145731
https://doi.org/10.2174/1389203717666160322145731
Autor:
Janice Perry Evans, Phyllis C. Leppert
Publikováno v:
Connective Tissue Research. 57:236-244
Reproductive biologists are well-versed in many types of biochemical signaling, and indeed, there are almost innumerable examples in reproduction, including steroid and peptide hormone signaling, receptor-ligand and secondary messenger-mediated signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc25a296aaeb927aff59265ab93e26c9
https://doi.org/10.3109/03008207.2016.1146715
https://doi.org/10.3109/03008207.2016.1146715
Autor:
Leland J. Foshag, Susan Love, Charles W. Nager, Timothy D. Johnson, Sarah J. Kilpatrick, Guy I. Benrubi, Michael Frumovitz, Judy Norsigian, Scott C. Goodwin, G. David Adamson, Eva Chalas, Jonathan S. Berek, Elizabeth A. Pritts, Carla Dionne, Hugh S. Taylor, David S. Guzick, Phyllis C. Leppert, John O.L. DeLancey, Ayman Al-Hendy, Robert Israel, Barbara A. Goff, Sawsan As-Sanie, Cindy Farquhar, Andrew M. Kaunitz, Rosanne M. Kho, Linda D. Bradley, R. Kevin Reynolds, Ted L. Anderson, Richard J. Paulson, David L. Olive, G. Larry Maxwell, Marie Fidela R. Paraiso, Stacey A. Scheib, John R. Lurain, Amanda N. Fader, William Parker, Charles Ascher-Walsh, Anton J. Bilchik, Robin Farias-Eisner, Daniel L. Clarke-Pearson, Robert E. Bristow, Steven S. Raman, Matthew T. Siedhoff, Laurel W. Rice, Alison Jacoby, William E. Gibbons
Publikováno v:
Journal of Minimally Invasive Gynecology. 23:303-308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07f4d99424622af54f1273d70e9d642
https://doi.org/10.1016/j.jmig.2015.12.012
https://doi.org/10.1016/j.jmig.2015.12.012