Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Phylicia, Aaron"'
Autor:
Minal Barve, Phylicia Aaron, Luisa Manning, Ernest Bognar, Gladice Wallraven, Staci Horvath, Laura Stanbery, John Nemunaitis
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 16 (2022)
Background: Gemogenovatucel-T (Vigil) is a triple-function autologous tumor cell immunotherapy which expresses granulocyte-macrophage colony-stimulating factor and decreases expression of furin and downstream TGF-β1 and TGF-β2. Vigil has suggested
Externí odkaz:
https://doaj.org/article/b2dba5de4aa74292a27b20a8dde927db
Autor:
Jonathan Oh, Minal Barve, Neil Senzer, Phylicia Aaron, Luisa Manning, Gladice Wallraven, Ernest Bognar, Laura Stanbery, Staci Horvath, Meghan Manley, John Nemunaitis, Adam Walter, Rodney P. Rocconi
Publikováno v:
Gynecologic Oncology Reports, Vol 36, Iss , Pp 100740- (2021)
Externí odkaz:
https://doaj.org/article/d3baaded57ca4fd4a1e40a9521b07521
Autor:
Johnathan Oh, Minal Barve, Neil Senzer, Phylicia Aaron, Luisa Manning, Gladice Wallraven, Ernest Bognar, Laura Stanbery, Staci Horvath, Meghan Manley, John Nemunaitis, Adam Walter, Rodney P. Rocconi
Publikováno v:
Gynecologic Oncology Reports, Vol 34, Iss , Pp 100648- (2020)
Externí odkaz:
https://doaj.org/article/e43f4809d0e54d0cba6c51742a18b756
Autor:
Rodney P. Rocconi, Laura Stanbery, Luciana Madeira da Silva, Robert A. Barrington, Phylicia Aaron, Luisa Manning, Staci Horvath, Gladice Wallraven, Ernest Bognar, Adam Walter, John Nemunaitis
Publikováno v:
Vaccines, Vol 9, Iss 8, p 894 (2021)
Aim: To determine the relationship between gene expression profile (GEP) and overall survival (OS) by NanoString following treatment with Vigil. Patients and Methods: Recurrent ovarian cancer patients (n = 21) enrolled in prior clinical trials. Resul
Externí odkaz:
https://doaj.org/article/1ae2462f0f274e798495bd404584b2e1
Autor:
Robert L. Coleman, Adam Walter, Rodney P. Rocconi, Neil Senzer, Laura Stanbery, Ernest Bognar, Luisa Manning, Evanthia Galanis, Thomas J. Herzog, Bradley J. Monk, Gladice Wallraven, John Nemunaitis, Phylicia Aaron
Publikováno v:
Gynecologic Oncology. 161:676-680
Recently, Vigil showed significant clinical benefit with improvement in relapse free (RFS) and overall survival (OS) in pre-planned subgroup analysis in stage III/IV newly diagnosed ovarian cancer patients with BRCA wild type (BRCA-wt) molecular prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab2cf47c76bd6334666e77b96b27a18
https://doi.org/10.1016/j.ygyno.2021.03.009
https://doi.org/10.1016/j.ygyno.2021.03.009
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer
Autor:
Luisa Manning, Bradley J. Monk, Phylicia Aaron, Evanthia Galanis, Staci Horvath, Rodney P. Rocconi, Thomas J. Herzog, Erin E. Stevens, Adnan R. Munkarah, Meghan Manley, Sharad A. Ghamande, Justin N. Bottsford-Miller, Gladice Wallraven, John Nemunaitis, Adam Walter, Robert L. Coleman, Jeffrey Elder, Leslie L. DeMars, Laura Stanbery, Ernest Bognar
Publikováno v:
Cancer Gene Therapy. 29:369-382
Vigil® is a personalized vaccine that enhances tumor neoantigen expression. We investigated for the first time safety and efficacy of Vigil in combination with atezolizumab in relapsed ovarian cancer (OC) patients. This is a randomized, Phase 1 stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0220c0e11bf3dd7327de5fed5f7a2d3b
https://doi.org/10.1038/s41417-021-00317-5
https://doi.org/10.1038/s41417-021-00317-5
Autor:
Minal A. Barve, Devansu Tewari, Rodney P. Rocconi, Justin Bottsford-Miller, Gladice Wallraven, Laura Stanbery, John Nemunaitis, Bradley J. Monk, Brian M. Slomovitz, Peter C. Morris, Robert L. Coleman, Thomas J. Herzog, Phylicia Aaron, David M. Shanahan, Jonathan C. Oh, Erin E. Stevens, Elizabeth A. Grosen, John K. Chan, Staci Horvath, Sharad A. Ghamande, Luisa Manning, Ernest Bognar, Min Tang
Publikováno v:
The Lancet Oncology. 21:1661-1672
Summary Background Gemogenovatucel-T is an autologous tumour cell vaccine manufactured from harvested tumour tissue, which specifically reduces expression of furin and downstream TGF-β1 and TGF-β2. The aim of this study was to determine the safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f8cb1c5ab1c279408411411ca87bc5
https://doi.org/10.1016/s1470-2045(20)30533-7
https://doi.org/10.1016/s1470-2045(20)30533-7
Autor:
Rodney P. Rocconi, Bradley J. Monk, Adam Walter, Thomas J. Herzog, Evanthia Galanis, Luisa Manning, Ernest Bognar, Gladice Wallraven, Laura Stanbery, Phylicia Aaron, Neil Senzer, Robert L. Coleman, John Nemunaitis
Publikováno v:
Gynecologic Oncology. 169:173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4c55fbbda29ceb3e8b55af468fc8c2
https://doi.org/10.1016/j.ygyno.2022.11.010
https://doi.org/10.1016/j.ygyno.2022.11.010
Autor:
John Nemunaitis, Phylicia Aaron, David Willoughby, Elyssa Sliheet, Khalil Choucair, Susan Morand, Molly Robinson, Ernest Bognar, Laura Stanbery
Publikováno v:
Cancer gene therapy. 29(7)
Thus far immunotherapy has had limited impact on ovarian cancer. Vigil (a novel DNA-based multifunctional immune-therapeutic) has shown clinical benefit to prolong relapse-free survival (RFS) and overall survival (OS) in the BRCA wild type and HRP po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fa475dc5066558087d16b54dea85c3
https://pubmed.ncbi.nlm.nih.gov/34785763
https://pubmed.ncbi.nlm.nih.gov/34785763
Autor:
Adam Walter, Bradley J. Monk, Thomas J. Herzog, Robert L. Coleman, Gladice Wallraven, John Nemunaitis, Laura Stanbery, Phylicia Aaron, Luisa Manning, Rodney P. Rocconi, Staci Horvath, Ernest Bognar, Min Tang
Publikováno v:
Gynecologic oncology. 163(3)
Objective Previously, Vigil demonstrated clinical benefit to prolong relapse free and overall survival in the BRCA wild-type (BRCA-wt), homologous recombination proficient (HRP) patient population. Here we provide long term follow up of 3 years in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bb2a0c029965350dbecfed54557dd6
https://pubmed.ncbi.nlm.nih.gov/34702567
https://pubmed.ncbi.nlm.nih.gov/34702567