Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Phuoc My Nguyen"'
Autor:
Styliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, Andreas Müller, Affiong Ika Oqua, Alejandra Tomas, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113992- (2024)
Summary: Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contac
Externí odkaz:
https://doaj.org/article/ab020b44d66c4d84917ebea44d0e0a85
Autor:
Styliani Panagiotou, Phuoc My Nguyen, Kia Wee Tan, Andreas Müller, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren
Insulin secretion is the process whereby insulin-containing granules fuse with the plasma membrane of β-cells. Exocytosis is preceded by cargo loading, maturation and transport of the secretory granules; processes that require modification of both t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80ed8e01526a5cd986704e976a63f11
https://doi.org/10.1101/2023.02.22.529485
https://doi.org/10.1101/2023.02.22.529485
Autor:
Gonzalo Manuel, Sanchez, Tugce Ceren, Incedal, Juan, Prada, Paul, O'Callaghan, Oleg, Dyachok, Santiago, Echeverry, Özge, Dumral, Phuoc My, Nguyen, Beichen, Xie, Sebastian, Barg, Johan, Kreuger, Thomas, Dandekar, Olof, Idevall-Hagren
Publikováno v:
The Journal of cell biology. 222(1)
The primary cilium is an organelle present in most adult mammalian cells that is considered as an antenna for sensing the local microenvironment. Here, we use intact mouse pancreatic islets of Langerhans to investigate signaling properties of the pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd1eb616799fabea47a19fd4021e5af9
https://pubmed.ncbi.nlm.nih.gov/36350286
https://pubmed.ncbi.nlm.nih.gov/36350286
Autor:
Beichen Xie, Phuoc My Nguyen, Paul O'Callaghan, T. C. Incedal, Olof Idevall-Hagren, S. Echeverry, Johan Kreuger, Juan P. Prada Salcedo, Thomas Dandekar, Sebastian Barg, Gonzalo Sanchez
The primary cilium is an organelle present in most adult mammalian cells and is thought of as an antenna for detection of a variety of signals. Here we use intact mouse pancreatic islets of Langerhans to investigate signalling properties of the prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500f7c6c09cf897265b7eadb695b9451
https://doi.org/10.1101/2021.08.16.456473
https://doi.org/10.1101/2021.08.16.456473
Autor:
Sari Sugahara, Beichen Xie, Olof Idevall-Hagren, Phuoc My Nguyen, Yingke Xu, Nikhil R. Gandasi
Publikováno v:
The Journal of Cell Biology
Nguyen et al. find that the PI(4)P phosphatase Sac2 localizes to insulin granules, where it controls granule docking to the plasma membrane. Loss of Sac2 results in impaired insulin secretion, and Sac2 mRNA levels are reduced in type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88824701b8935b525aef16adcb53439
https://doi.org/10.1083/jcb.201903121
https://doi.org/10.1083/jcb.201903121
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4)
Endoplasmic reticulum (ER)-plasma membrane (PM) contacts are dynamic structures with important roles in the regulation of calcium (Ca2+) and lipid homeostasis. The extended synaptotagmins (E-Syts) are ER-localized lipid transport proteins that intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f663ef1bab9b1be2f4b20720f61776
https://pubmed.ncbi.nlm.nih.gov/30589572
https://pubmed.ncbi.nlm.nih.gov/30589572
Autor:
Beichen Xie, Alenka Guček, Phuoc My Nguyen, Sebastian Barg, Antje Thonig, Olof Idevall-Hagren
Publikováno v:
Cell Chemical Biology. 23:816-826
Insulin secretion from pancreatic β cells is regulated by the blood glucose concentration and occurs through Ca(2+)-triggered exocytosis. The activities of multiple ion channels in the β cell plasma membrane are required to fine-tune insulin secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24fbd2bf42be3a7242296beeeb3dc35
https://doi.org/10.1016/j.chembiol.2016.06.009
https://doi.org/10.1016/j.chembiol.2016.06.009
Akademický článek
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Akademický článek
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Publikováno v:
FASEB Journal; Apr2019, Vol. 33 Issue 4, p4716-4728, 13p