Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Phu N Tran"'
Autor:
Ming Ren, Aaron L Randolph, Claudia Alvarez-Baron, Donglin Guo, Phu N Tran, Nicolas Thiebaud, Jiansong Sheng, Jun Zhao, Wendy W Wu
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276995 (2022)
Background and purposeCaV1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling. Understanding drug action on CaV1.2 channels may inform potential i
Externí odkaz:
https://doaj.org/article/0ed99cc9c9064ac28b84b9d7a7da82fd
Autor:
Phu N Tran, Jiansong Sheng, Aaron L Randolph, Claudia Alvarez Baron, Nicolas Thiebaud, Ming Ren, Min Wu, Lars Johannesen, Donna A Volpe, Dakshesh Patel, Ksenia Blinova, David G Strauss, Wendy W Wu
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241362 (2020)
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transd
Externí odkaz:
https://doaj.org/article/bc6642b0a596431cad433e68b1c4b7cd
Publikováno v:
IEEE Access, Vol 10, Pp 17881-17896 (2022)
Aircraft trajectory prediction is a challenging problem in air traffic control, especially for conflict detection. Traditional trajectory predictors require a variety of inputs such as flight-plans, aircraft performance models, meteorological forecas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1da11206ae5ddfb118c1bbbe964eab
https://doi.org/10.1109/access.2022.3149231
https://doi.org/10.1109/access.2022.3149231
Autor:
Sara Dutta, Kelly C. Chang, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Wendy W. Wu, Min Wu, David G. Strauss, Thomas Colatsky, Zhihua Li
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/7cb3dfac45fe48fcb343d667b19f9237
Autor:
Kelly C. Chang, Sara Dutta, Gary R. Mirams, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Min Wu, Wendy W. Wu, Thomas Colatsky, David G. Strauss, Zhihua Li
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic assays. Under the CiPA paradigm, the relative risk of drug-induced Torsade de Poin
Externí odkaz:
https://doaj.org/article/193af6d3340e4a5da1d7dd1cdf5456ae
Autor:
Sara Dutta, Kelly C. Chang, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Wendy W. Wu, Min Wu, David G. Strauss, Thomas Colatsky, Zhihua Li
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assa
Externí odkaz:
https://doaj.org/article/2286e562933b4de396d4a490623cce6a
Publikováno v:
Case Reports in Emergency Medicine, Vol 2017 (2017)
Despite the risk of cyanide toxicity and lack of efficacy, amygdalin is still used as alternative cancer treatment. Due to the highly lethal nature of cyanide toxicity, many patients die before getting medical care. Herein, we describe the case of a
Externí odkaz:
https://doaj.org/article/35c29278e0384faa863b540e397815db
Publikováno v:
2021 IEEE International Conference on Multimedia & Expo Workshops (ICMEW).
An airport runway and taxiway (airside) area is a highly dynamic and complex environment featuring interactions between different types of vehicles (speed and dimension), under varying visibility and traffic conditions. Airport ground movements are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daedd138e23d011f641ea0f99356997
https://doi.org/10.1109/icmew53276.2021.9456005
https://doi.org/10.1109/icmew53276.2021.9456005
Publikováno v:
The Journal of Vascular Access. 21:300-307
Introduction:Catheter-related right atrial thrombosis is an under-recognized complication of central venous catheter placement. We performed a retrospective review, characterizing clinical aspects of catheter-related right atrial thrombosis (CRAT).Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7f869379dfa79d124b3093885ac008
https://doi.org/10.1177/1129729819873851
https://doi.org/10.1177/1129729819873851
Autor:
Nadine Becker, Mohammadreza Samieegohar, John Imredy, Jin Zhai, Anders Lindqvist, Søren Friis, Nina Brinkwirth, Tim Strassmaier, Jae Kwagh, James Kramer, Jingsong Fan, Paul Levesque, Sonja Stoelzle-Feix, Bradley J. Ridder, Herbert Himmel, Timm Danker, Derek J. Leishman, Markus Rapedius, Liudmila Polonchuk, Jiansong Sheng, Marc Rogers, Gary R. Mirams, Simon Hebeisen, Haiyang Wei, George Okeyo, Evgenia Gissinger, Tom A. Goetze, Phu N. Tran, Zhihua Li, Rémi Bardenet, Yuri A. Kuryshev, Muthukrishnan Renganathan, Maria Giustina Rotordam, Aaron Randolph, Daniel Konrad, Robert W. Kirby, Wendy W. Wu, Caiyun Wu, David G. Strauss, Matthew Bridgland-Taylor, Bryan Koci, Edward Humphries, Xiaomei Han
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Introduction hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e258ca318d261e63e5e97ce793630
http://europepmc.org/articles/PMC7166077
http://europepmc.org/articles/PMC7166077