Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Photini Sinnis"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Malaria is initiated when infected anopheline mosquitoes inoculate sporozoites as they probe for blood. It is thought that all infected mosquitoes are equivalent in terms of their infectious potential, with parasite burden having no role in
Externí odkaz:
https://doaj.org/article/36d12afc8d644f59bbdf13589a8d3cb6
Autor:
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema
Publikováno v:
eLife, Vol 12 (2024)
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso. We quantified th
Externí odkaz:
https://doaj.org/article/be98e34cc5dd4122ad803aa3d9086ded
Autor:
Victoria A. Balta, Deborah Stiffler, Abeer Sayeed, Abhai K. Tripathi, Rubayet Elahi, Godfree Mlambo, Rahul P. Bakshi, Amanda G. Dziedzic, Anne E. Jedlicka, Elizabeth Nenortas, Keyla Romero-Rodriguez, Matthew A. Canonizado, Alexis Mann, Andrew Owen, David J. Sullivan, Sean T. Prigge, Photini Sinnis, Theresa A. Shapiro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine durability. However, selection and transmission of drug-resistant parasites is of concer
Externí odkaz:
https://doaj.org/article/4b2f7c80b9964c198820bdffbbda7944
Autor:
Gayani Batugedara, Xueqing M. Lu, Borislav Hristov, Steven Abel, Zeinab Chahine, Thomas Hollin, Desiree Williams, Tina Wang, Anthony Cort, Todd Lenz, Trevor A. Thompson, Jacques Prudhomme, Abhai K. Tripathi, Guoyue Xu, Juliana Cudini, Sunil Dogga, Mara Lawniczak, William Stafford Noble, Photini Sinnis, Karine G. Le Roch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. Increasing evidence now suggests a major role for epigenetic mechanisms in gene ex
Externí odkaz:
https://doaj.org/article/f2a81b4d714045ac8d01aa238cd881cc
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Autor:
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Aswathy Sebastian, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Istvan Albert, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/1ca482631bb9409da5bdd049a070649e
Autor:
Gibran Nasir, Photini Sinnis
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0273960 (2023)
The dermis is the portal of entry for most vector-transmitted pathogens, making the host's immune response at this site critical in mitigating the magnitude of infection. For malaria, antibody-mediated neutralization of Plasmodium parasites in the de
Externí odkaz:
https://doaj.org/article/0a1a09abae9442d8960136a066a3ac8c
Autor:
Christine S Hopp, Sachie Kanatani, Nathan K Archer, Robert J Miller, Haiyun Liu, Kevin K Chiou, Lloyd S Miller, Photini Sinnis
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-18 (2021)
Abstract Malaria infection starts with the injection of Plasmodium sporozoites into the host’s skin. Sporozoites are motile and move in the skin to find and enter blood vessels to be carried to the liver. Here, we present the first characterization
Externí odkaz:
https://doaj.org/article/763c09052d3e45d58e9e143e0a52fd2f
Autor:
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Here, the authors report transcriptomes and proteomes of oocyst sporozoite and salivary gland sporozoite stages in rodent-infectious Plasmodium yoelii parasites and human infectious Plasmodium falciparum parasites and define two waves of translationa
Externí odkaz:
https://doaj.org/article/008124ab714a455090e9902fd95469da
Autor:
Kyle Jarrod McLean, Judith Straimer, Christine S. Hopp, Joel Vega-Rodriguez, Jennifer L. Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C. Dumoulin, Chantal T. Harris, Xinran Tong, Melanie J. Shears, Johan Ankarklev, Björn F. C. Kafsack, David A. Fidock, Photini Sinnis
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Malaria parasites have a complex life cycle that includes specialized stages for transmission between their mosquito and human hosts. These stages are an understudied part of the lifecycle yet targeting them is an essential component of the
Externí odkaz:
https://doaj.org/article/6cd4b2ab743b40668a54bf07aa368fc2