Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Phosphoribosylaminoimidazole carboxylase"'
Autor:
Timothy D. Cummins, Teresa Cassel, William L. Dean, Bradford G. Hill, Michael L. Merchant, Teresa W.-M. Fan, Yuting Zheng, Pawel Lorkiewicz, Timothy N. Audam, Kyle L Fulghum
Publikováno v:
Journal of molecular and cellular cardiology
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the f
Autor:
Qiting Yao, Maomao Guo, Xiaosha Zhang, Qingchun Zhou, Xiaoting Liang, Gongyu Xu, Hao Shen, Haobin Zhao, Abdullah Al Hafiz, Xueping Zhong
Publikováno v:
Protein & Peptide Letters. 27:971-978
Background: Prmt5 plays major role in regulation of gene expression, RNA processing, cell growth and differentiation, signal transduction, germ cell development, etc., in mammals. Prmt5 is also related to cancer. Knowing the proteins interacting with
Autor:
Xi Chen, Jie Wei, Yuanliang Yan, Long Qian, Zhicheng Gong, Yangying Zhou, Xue Yang, Xiang Wang, Shuyi Zhou, Shuangshuang Zeng, Zhijie Xu
Publikováno v:
Gene. 692:1-8
Background Phosphoribosylaminoimidazole carboxylase (PAICS), a de novo purine metabolic enzyme, has been identified as an oncogene in several tumor types, including breast cancer and prostate cancer. However, the role of PAICS in human lung adenocarc
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1990 Apr 01. 87(8), 2916-2920.
Externí odkaz:
https://www.jstor.org/stable/2354069
Autor:
Randall C. Mazzarino, David Patterson, Terry G. Wilkinson, Marie Zikanova, Guido N. Vacano, Veronika Baresova, Nathan Duval
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss, Pp 100642-(2020)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
In de novo purine biosynthesis (DNPS), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (EC 2.1.2.3)/inosine monophosphate cyclohydrolase (EC 3.5.4.10) (ATIC) catalyzes the last two reactions of the pathway: conversion of 5-aminoimidaz
Autor:
Shuping Long, Xue Li, Chang Xu, Fenyong Sun, Zhixuan Bian, Yue Zhang, Guohui Li, Yan Chen, Ni Zhen, Nan Huang, Liang Deng
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 7, Pp 1-13 (2020)
Cell Death and Disease, Vol 11, Iss 7, Pp 1-13 (2020)
Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an essential enzyme involved in de novo purine biosynthesis, is connected with formation of various tumors. However, the specific biological
Publikováno v:
Applied microbiology and biotechnology. 104(6)
Ophiocordyceps sinensis, one of the well-known and precious fungal species in the world, parasitizes soil-dwelling larvae of ghost moths on the Tibetan Plateau. The genetic intractability of this extremely psychrophilic and slow-growing O. sinensis f
Autor:
Nirzari Gupta, Sooryanarayana Varambally, Darshan S. Chandrashekar, Balabhadrapatruni V. S. K. Chakravarthi, Prachi Bajpai, Cherlene Y. Hardy, Hyung-Gyoon Kim, Sai Akshaya Hodigere Balasubramanya, Sameer Al Diffalha, Sumit Agarwal, Amr Elkholy, Michael Behring, Upender Manne
Publikováno v:
Cancers
Cancers, Vol 12, Iss 4, p 772 (2020)
Volume 12
Issue 4
Cancers, Vol 12, Iss 4, p 772 (2020)
Volume 12
Issue 4
The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient survival. We investigated the functional role of phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succin
Autor:
Fumihiko Nakao, Takahiro Maeda, Daniel E. Bauer, Matthew C. Canver, Luca Pinello, Jumpei Nogami, Takeshi Sugio, Deborah Taylor, Takuji Yamauchi, Koichi Akashi, Simon Osborne, Kensuke Sasaki, Yuichiro Semba, Kohta Miyawaki
Publikováno v:
Blood. 134:1390-1390
Progress has been made in deciphering molecular mechanisms underlying AML pathogenesis due in part to near-complete understanding of AML genomes. However, AML is yet a devastating disease with a long-term survival rate of less than 30%, underscoring
Autor:
Sooryanarayana Varambally, Nallasivam Palanisamy, Arul M. Chinnaiyan, Balabhadrapatruni V. S. K. Chakravarthi, Darshan S. Chandrashekar, Robert J. Lonigro, Moloy T. Goswami, Javed Siddiqui, Sumit Agarwal, Saroj Nepal, Sai Akshaya Hodigere Balasubramanya, Satya S. Pathi, Matthew Dodson, Lakshmi P. Kunju
Publikováno v:
The Prostate. 78(9)
BACKGROUND Our goal was to investigate de novo purine biosynthetic gene PAICS expression and evaluate its role in prostate cancer progression. METHODS Next-generation sequencing, qRTPCR and immunoblot analysis revealed an elevated expression of a de