Zobrazeno 1 - 10
of 2 260
pro vyhledávání: '"Phosphoramidate"'
Autor:
O. Sergeeva, E. Akhmetova, S. Dukova, E. Beloglazkina, A. Uspenskaya, A. Machulkin, D. Stetsenko, T. Zatsepin
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Phosphorothioate (PS) group is a key component of a majority of FDA approved oligonucleotide drugs that increase stability to nucleases whilst maintaining interactions with many proteins, including RNase H in the case of antisense oligonucleotides (A
Externí odkaz:
https://doaj.org/article/f7426a52b63642beb615f5dcfae96589
Publikováno v:
Molecules, Vol 29, Iss 12, p 2714 (2024)
In this study, we report a novel per-6-substituted β-cyclodextrin (4) featuring seven phosphoramidate moieties as an innovative host for inclusion. This structurally well-defined host has remarkable water solubility and was isolated in pure form. An
Externí odkaz:
https://doaj.org/article/b796349912bf4f98b5d30c72131650bd
Autor:
Andrzej Kutner
Publikováno v:
Journal of Medical Science, Vol 92, Iss 3 (2023)
Bioavailability is a prerequisite for drug activity. In vivo bioavailability (intestinal permeability), linked to drug substance solubility and drug product dissolution, became the basis of Gordon L. Amidon’s Biopharmaceutical Classification System
Externí odkaz:
https://doaj.org/article/71cf5909c49d47e189225f52832c8f19
Autor:
Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1315-1319 (2022)
Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or su
Externí odkaz:
https://doaj.org/article/a9ccf5c5ec2d408eafe85ab37d1e230c
Autor:
Timofey D. Zharkov, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Publikováno v:
Molecules, Vol 29, Iss 2, p 452 (2024)
Numerous types of oligonucleotide modifications have been developed since automated synthesis of DNA/RNA became a common instrument in the creation of synthetic oligonucleotides. Despite the growing number of types of oligonucleotide modifications un
Externí odkaz:
https://doaj.org/article/3bcef87e6cb04dc7a30f8b46ce5cd0a3
Autor:
Irina Bauer, Ekaterina Ilina, Timofey Zharkov, Evgeniya Grigorieva, Olga Chinak, Maxim Kupryushkin, Victor Golyshev, Dmitry Mitin, Alexey Chubarov, Svetlana Khodyreva, Elena Dmitrienko
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2779 (2023)
Lipophilic oligonucleotide derivatives are a potent approach to the intracellular delivery of nucleic acids. The binding of these derivatives to serum albumin is a determinant of their fate in the body, as its structure contains several sites of high
Externí odkaz:
https://doaj.org/article/0586ed168ded43498789a4b91945a100
Akademický článek
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Autor:
Timofey D. Zharkov, Ekaterina M. Mironova, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14637 (2023)
Lipophilic oligonucleotide conjugates represent a powerful tool for nucleic acid cellular delivery, and many methods for their synthesis have been developed over the past few decades. In the present study, a number of chemical approaches for the synt
Externí odkaz:
https://doaj.org/article/a6cd213e133a4aa28164185514efc1bc
Akademický článek
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Autor:
Mahboobeh Sharifi, Nargess Memarizadeh, Mohammad Ghadamyari, Khodayar Gholivand, Ali Asghar Ebrahimi Valmoozi
Publikováno v:
Journal of Crop Protection, Vol 10, Iss 3, Pp 585-596 (2021)
Organophosphates (OPs), one of the most important pesticide groups, are used worldwide to control pests. Acetylcholinesterase (EC 1.14.18.1) (AChE), an enzyme from insects’ nervous systems, is the leading target site of this group of pesticides, su
Externí odkaz:
https://doaj.org/article/efae9bf08e9f42dc84e3dddc26c536ad