Výsledky vyhledávání - "Phospholipid Signaling Cascade"

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function

Autor: Mitchell E. Granade, Thurl E. Harris, Rosalie G. Hoyle, Brittany A. Martinez, Michelle L. Bland, J. David Castle, Scott Yeudall, Norbert Leitinger

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009192 (2020)

During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ead1047a870030261a59fffb62b23c6
https://doi.org/10.1371/journal.pgen.1009192

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Novel Lysophospholipid Acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b Responsible for Generation of Palmitate-Docosahexaenoate-Phosphatidylcholine and Phosphatidylethanolamine

Autor: Daiske Honda, Eri Nutahara, Eriko Abe, Kosaku Doi, Ryo Taguchi, Makoto Ito, Kazutaka Ikeda, Masahiro Hayashi, Atsushi Yamashita, Nozomu Okino

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e102377 (2014)

N-3 polyunsaturated fatty acids (PUFA), such as docosahexaenoic acid (DHA, 22:6n-3), have been reported to play roles in preventing cardiovascular diseases. The major source of DHA is fish oils but a recent increase in the global demand of DHA and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c98d772704f62132a303b4b4610814
http://europepmc.org/articles/PMC4121067

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Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

Autor: Mark O. Collins, Jyoti S. Choudhary, Frank Schwach, David A. Baker, Oliver Billker, Mathieu Brochet, Sarah Sebastian, Eloise Thompson, Terry K. Smith, Julian C. Rayner, Katrin Volkmann, Lia Chappell, Ana Rita Gomes, Matthew Berriman

Publikováno v: PLoS Biology

Chemical genetics and a global comparative analysis of phosphorylation and phospholipids in vivo shows that PKG is the upstream regulator that induces calcium signals that enables Plasmodium to progress through its complex life cycle.
Many criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c792bb6c970837aeed6d45c3e4297437
http://europepmc.org/articles/PMC3942320

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Lipid profiles alter from pro-atherogenic into less atherogenic and proinflammatory in juvenile idiopathic arthritis patients responding to anti TNF-α treatment

Autor: Yu-Jr Lin, Jing-Long Huang, Chee-Jen Chang, Chi-Ming Lee, Kuo-Wei Yeh

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e90757 (2014)
PLoS ONE

Objective Dyslipidemia with higher inflammatory states, disease activity, and longer disease duration in juvenile idiopathic arthritis (JIA) patients seemed to increase the risks of atherosclerosis. Tumor necrosis factor- α (TNF-α) receptor blockin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd47c21e003acf5e027454ae6499db2d
http://europepmc.org/articles/PMC3948338?pdf=render

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Fatty acids from membrane lipids become incorporated into lipid bodies during Myxococcus xanthus differentiation

Autor: Tye O. Boynton, Dan Pham, Lawrence J. Shimkets, Swapna Bhat

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99622 (2014)
PLoS ONE

Myxococcus xanthus responds to amino acid limitation by producing fruiting bodies containing dormant spores. During development, cells produce triacylglycerides in lipid bodies that become consumed during spore maturation. As the cells are starved to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ce8256dbe33410e8e4c17ab2f0b54c
http://europepmc.org/articles/PMC4048283?pdf=render

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The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness

Autor: Elena Rainero, Nicoletta Filigheddu, Cristina Cianflone, Valeria Malacarne, Gianluca Baldanzi, Jim C. Norman, Irene Locatelli, Fabiola Sinigaglia, Wolfgang Paster, Daniela Capello, Fabio Benecchia, Valentina Bettio, Federica Chianale, Alessandra Bertoni, Andrea Graziani, Elisa Ruffo, Paolo E. Porporato, Michele Ferrara

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e97144 (2014)
PLoS One, Vol. 9, no. 6, p. e97144 (2014)
PLoS ONE

Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245a8a7b96278169fc65e2223a148131
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0097144&representation=PDF

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Visualization of phosphatidic acid fluctuations in the plasma membrane of living cells

Autor: Juan Llopis, José P. Ferraz-Nogueira, F. Javier Díez-Guerra

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102526 (2014)
PLoS ONE

We developed genetically-encoded fluorescent sensors based on Forster Resonance Energy Transfer to monitor phosphatidic acid (PA) fluctuations in the plasma membrane using Spo20 as PA-binding motif. Basal PA levels and phospholipase D activity varied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0187fe3b286484c8081135c4d56360
http://europepmc.org/articles/PMC4099201?pdf=render

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Rac1-dependent lamellipodial motility in prostate cancer PC-3 cells revealed by optogenetic control of Rac1 activity

Autor: Katsuhisa Kawai, Nobukazu Araki, Yoshiyuki Kakehi, Takuma Kato, Youhei Egami

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97749 (2014)
PLoS ONE

The lamellipodium, an essential structure for cell migration, plays an important role in the invasion and metastasis of cancer cells. Although Rac1 recognized as a key player in the formation of lamellipodia, the molecular mechanisms underlying lamel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15dc6012c317ce0ddffe19d1e93093f
http://europepmc.org/articles/PMC4029798?pdf=render

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Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation

Autor: Yan Xu, Angelica Schehr, Liya Huo, Machiko Ikegami, James P. Bridges, Jeffrey A. Whitsett, Yanhua Wang, Valérie Besnard

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e91376 (2014)

Pulmonary surfactant is required for lung function at birth and throughout postnatal life. Defects in the surfactant system are associated with common pulmonary disorders including neonatal respiratory distress syndrome and acute respiratory distress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18df1475d6b0942002277f441c82540
https://pubmed.ncbi.nlm.nih.gov/24806461

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Responses of the insulin signaling pathways in the brown adipose tissue of rats following cold exposure

Autor: Xiaofei Wang, Richard L. Wahl

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e99772 (2014)

UNLABELLED The insulin signaling pathway is critical for the control of blood glucose levels. Brown adipose tissue (BAT) has also been implicated as important in glucose homeostasis. The effect of short-term cold exposure on this pathway in BAT has n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10ac6df61068a3c7dea280170c0b5dc
https://pubmed.ncbi.nlm.nih.gov/24915042

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