Peri active site catalysis of proline isomerisation is the molecular basis of allomorphy in β-phosphoglucomutase.

Autor: Cruz-Navarrete FA; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Baxter NJ; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.; Manchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, Manchester, M1 7DN, UK., Flinders AJ; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.; Cancer Research UK, Manchester Institute, Patterson Building, Manchester, M20 4BX, UK., Buzoianu A; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.; Department of Chemistry, Biochemistry and Pharmacy, University of Bern, Bern, 3012, Switzerland., Cliff MJ; Manchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, Manchester, M1 7DN, UK., Baker PJ; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK., Waltho JP; School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK. j.waltho@sheffield.ac.uk.; Manchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, Manchester, M1 7DN, UK. j.waltho@sheffield.ac.uk.

Publikováno v: Communications biology [Commun Biol] 2024 Jul 27; Vol. 7 (1), pp. 909. Date of Electronic Publication: 2024 Jul 27.

Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase.

Autor: Carroll-Poehls M; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada., Jakeman DL; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada; College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada. Electronic address: david.jakeman@dal.ca.

Publikováno v: Carbohydrate research [Carbohydr Res] 2023 Dec; Vol. 534, pp. 108979. Date of Electronic Publication: 2023 Nov 02.

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Peri active site catalysis of proline isomerisation is the molecular basis of allomorphy in β-phosphoglucomutase

Autor: F. Aaron Cruz-Navarrete, Nicola J. Baxter, Adam J. Flinders, Anamaria Buzoianu, Matthew J. Cliff, Patrick J. Baker, Jonathan P. Waltho

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract Metabolic regulation occurs through precise control of enzyme activity. Allomorphy is a post-translational fine control mechanism where the catalytic rate is governed by a conformational switch that shifts the enzyme population between forms

Externí odkaz: https://doaj.org/article/3a6f90adbcce473198152379b2b8647a

Expression and Clinical Significance of Nuclear Phosphoglucomutase-1 in Hepatocellular Carcinoma.

Autor: Xia Y; Hongqiao International Institute of Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai., An Y; Hongqiao International Institute of Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai., Jin R; Department of First Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University., Huang W; Department of Pathology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai., Jin GZ; Department of Pathology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai., Xu J; Department of Laboratory Medicine, Wuxi Traditional Chinese Medicine Hospital, Wuxi, China.

Publikováno v: Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2024 Nov-Dec 01; Vol. 32 (10), pp. 476-483. Date of Electronic Publication: 2024 Sep 20.