Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

Autor: Shenggui Xu, Xiankun Cao, Zhenxing Yu, Wenxin He, Yichuan Pang, Wang Lin, Zhiqian Chen, Weizhong Guo, Xiongwei Lu, Chengshou Lin

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorptio

Externí odkaz: https://doaj.org/article/c8bf445519324e2885e0226ba5dd5fad

'Three Methods and Three Points' regulates p38 mitogen-activated protein kinase in the dorsal horn of the spinal cord in a rat model of sciatic nerve injury

Autor: Xin Guo, Tian-yuan Yu, Wong Steven, Wen-duan Jia, Chi Ma, Yan-hong Tao, Chao Yang, Tao-tao Lv, Shuai Wu, Meng-qian Lu, Jia-li Liu

Publikováno v: Neural Regeneration Research, Vol 11, Iss 12, Pp 2018-2024 (2016)

Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions and indices of the spinal dorsal horn using the Dian, Bo, and

Externí odkaz: https://doaj.org/article/88cb1045b74c48bca5fb71ce3912b279

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor

Autor: Monika A. Golinska, Marion Stubbs, Adrian L. Harris, Laszlo G. Boros, Madhu Basetti, Dominick J. O. McIntyre, John R. Griffiths

Publikováno v: Cells; Volume 11; Issue 22; Pages: 3595

Peer reviewed: True
Funder: CR UK PhD Studentship
The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a872c79cc568a96cacf70170d80b1eb0
https://www.repository.cam.ac.uk/handle/1810/343190

The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study

Autor: Laura Cabeza, Raúl Ortiz, Gloria Perazzoli, Jose Prados, Kevin Doello, Consolación Melguizo, Francisco Quiñonero, Cristina Mesas

Publikováno v: Cancers
Volume 13
Issue 13
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cancers, Vol 13, Iss 3169, p 3169 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

Sodium selenite acts by depleting enzymes that protect against cellular oxidative stress. To determine its effect alone or in combination with gemcitabine (GMZ) in pancreatic cancer, we used PANC-1 and Pan02 cell lines and C57BL mice bearing a Pan02-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f2843853b048b6507ff3a25ea78f3c
http://hdl.handle.net/10481/69466

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

Autor: Xiankun Cao, Xiongwei Lu, Yichuan Pang, Guo Weizhong, Zhiqian Chen, Lin Chengshou, Xu Shenggui, Wenxin He, Wang Lin, Yu Zhenxing

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef21aea8a376082879a17118c1c5cce6
http://europepmc.org/articles/PMC8455841