Zobrazeno 1 - 10 of 181 pro vyhledávání: '"Phosphatidylinositol 3-kinase signaling"'
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Phosphatidylinositol 3-kinase signaling inhibitors for treatment of multiple myeloma: From small molecules to microRNAs
Autor: Behrouz Farhadihosseinabadi, Maryam Nikoonezhad, Masoud Soleimani, Ghazaleh Sankanian, Arezou Sayad, Mahshid Mehdizadeh
Publikováno v: Journal of Oncology Pharmacy Practice. 28:149-158
Multiple myeloma is one of the most hard-to-treat cancers among blood malignancies due to the high rate of drug resistance and relapse. The researchers are trying to find more effective drugs for treatment of the disease. Hence, the use of drugs targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66578b25bc3cd0dd139605b4011ba70d
https://doi.org/10.1177/10781552211035369
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2
Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications
Autor: Tina Nguyen, Elissa K. Deenick, Stuart G. Tangye
Publikováno v: Expert Review of Clinical Immunology. 17:905-914
Introduction Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that plays a fundamental role in cell survival, metabolism, proliferation and differentiation. Thus, balanced PI3K signalling is critical for multiple aspects of human health. The di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ac2e4c296b5d0d152413b481dbd03b
https://doi.org/10.1080/1744666x.2021.1945443
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3
Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells
Autor: Stefan Schulte-Merker, Sasja Blokzijl-Franke, Philippe Herbomel, Jeroen den Hertog, Karima Kissa, Bas Ponsioen, Suma Choorapoikayil
Publikováno v: Oncogene
Oncogene, 40(15), 2741-2755. Nature Publishing Group
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cbdd02d3b1bfc9cf3985657e90560e
http://europepmc.org/articles/PMC8049872
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4
Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn’s disease via signaling involving distinct classes of phosphatidylinositol 3-kinases
Autor: Huangan Wu, Zheng Handan, Zhang Zhiying, Yan Huang, Wang Shiyuan, Huirong Liu, Luyi Wu, Min Zhao, Ji-Meng Zhao, Cili Zhou
Publikováno v: World Journal of Gastroenterology
BACKGROUND Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components. Recent studies have shown that autophagy plays an important role in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de9b1930f29a43434a96747febad195
https://doi.org/10.3748/wjg.v26.i39.5997
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5
CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice
Autor: Chunyu Zhang, Jia Li, Meijia Zhang, Yu Zhang, Nana Zheng, Jing Yang, Guoliang Xia, Biao Li
Publikováno v: Histochemistry and Cell Biology. 154:287-299
In mammals, progressive activation of primordial follicles is essential for maintenance of the reproductive lifespan. Several reports have demonstrated that mitogen-activated protein kinases 3 and 1 (MAPK3/1)-mammalian target of rapamycin complex 1 (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8d826b820bc56773d7c2585a72f75c
https://doi.org/10.1007/s00418-020-01888-4
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6
Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall
Autor: Silve Barrena, Felipe Sainz, Melchor Alvarez-Mon, Leonel Pekarek, Cielo García-Montero, Miguel A Ortega, Hector Montoya, Miguel Angel Alvarez-Mon, Fernando Ruiz-Grande, Luis G. Guijarro, Ángel Asúnsolo, Natalio García-Honduvilla, Julia Buján, Sofia Zoullas, Oscar Fraile-Martínez, Julio Acero
Publikováno v: The Journal of International Medical Research
Journal of International Medical Research, Vol 49 (2021)
Objectives Chronic venous disease (CVeD) is a multifactorial and debilitating condition that has a high prevalence in Western countries and an important associated socioeconomic burden. Varicose veins (VVs) are the most common manifestations of CVeD.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7862693c8e78a4a229e5aba07297c70a
https://pubmed.ncbi.nlm.nih.gov/34590920
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TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF
Autor: Pierre-Yves Desprez, Victoria Damerell, Ana Popovic, Colin R. Goding, Marie-Dominique Galibert, Sharon Prince, Jagat Chauhan, Jade Peres
Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2021, 141 (9), pp.2250-2260.e2. ⟨10.1016/j.jid.2021.02.740⟩
Journal of Investigative Dermatology, 2021, 141 (9), pp.2250-2260.e2. ⟨10.1016/j.jid.2021.02.740⟩
International audience; In melanoma, a phenotype switch from proliferation to invasion underpins metastasis, the major cause of melanoma-associated death. The transition from radial to vertical growth phase (invasive) melanoma is characterized by dow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c379c8cb0cfc831331331682b32a4e38
https://hal.archives-ouvertes.fr/hal-03221071/document
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8
Inhibitory Effect of PIK-24 on Respiratory Syncytial Virus Entry by Blocking Phosphatidylinositol-3 Kinase Signaling
Autor: Li-Feng Chen, Ding Luo, Neng-Hua Chen, Man-Mei Li, Wei-Bin Xu, Wei Tang, Yue-Yue Li, Zhong Liu, Zhi-Gang Huang, Qiao-Yun Song, Yao-Lan Li
Publikováno v: Antimicrob Agents Chemother
Phosphoinositide-3 kinase signaling modulates many cellular processes, including cell survival, proliferation, differentiation, and apoptosis. Currently, it is known that the establishment of respiratory syncytial virus infection requires phosphoinos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecb82afdfe54fe1a383b31a1f2e42fa
https://doi.org/10.1128/aac.00608-20
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10
TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity
Autor: Aaron J. Marshall, Affan A. Sher, Kimia Sheikholeslami, Nipun Jayachandran, Edgard M. Mejia, Grant M. Hatch, Sen Hou
Publikováno v: The Journal of Immunology. 201:406-416
Class I PI3K enzymes play critical roles in B cell activation by phosphorylating plasma membrane lipids to generate two distinct phosphoinositide (PI) products, PI(3,4,5)P3 and PI(3,4)P2. These PIs each bind distinct but overlapping sets of intracell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f7712c309022d32144473dd33e9dc
https://doi.org/10.4049/jimmunol.1701440
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