Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Phosphatidylinositol 3-Kinase/metabolism"'
Autor:
Shao-Pei Hung, Wen-Chin Lee, Hsiang-Hao Hsu, Jin-Bor Chen, You-Ying Chau, Terry Ting-Yu Chiou
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112349-(2021)
Chioua, T T-Y, Chau, Y-Y, Chen, J-B, Hsu, H-H, Huang, S-P & Lee, W-C 2021, ' Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway ', Biomedicine and Pharmacotherapy, vol. 144 . https://doi.org/10.1016/j.biopha.2021.112349
Chioua, T T-Y, Chau, Y-Y, Chen, J-B, Hsu, H-H, Huang, S-P & Lee, W-C 2021, ' Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway ', Biomedicine and Pharmacotherapy, vol. 144 . https://doi.org/10.1016/j.biopha.2021.112349
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults without diabetes. Primary MN has been associated with circulating antibodies against native podocyte antigens, including phospholipase A2 receptor (PLA2R); however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d35f5abc372da2d816d2bcd3713e5
https://doi.org/10.1016/j.biopha.2021.112349
https://doi.org/10.1016/j.biopha.2021.112349
Autor:
Mohammad Krayem, Catherine Sibille, Ghanem Elias Ghanem, Ahmad Awada, Murielle Wiedig, Ahmad Najem, Renato Morandini, Fabrice Journe, Jean-Christophe Marine, François Sales, Léon C van Kempen
Publikováno v:
European Journal of Cancer, 55, 98-110. ELSEVIER SCI LTD
Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by activation of the PI3K/AKT survival pathway, represents a major clinical challenge. Given that p53 is capable of antagonising PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a1e6bf491fe46c36749c7331f715ee
https://doi.org/10.1016/j.ejca.2015.12.002
https://doi.org/10.1016/j.ejca.2015.12.002
Publikováno v:
Biochemistry and Cell Biology
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩
International audience; Besides its direct metabolic effects, insulin induces transcriptional alterations in its target tissues. However, whether such changes are accompanied by epigenetic changes on the chromatin template encompassing insulin respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee74892e18d034649a649e0cef462
https://doi.org/10.1139/bcb-2013-0071
https://doi.org/10.1139/bcb-2013-0071
Autor:
Hervé Sartelet, Anne-Laure Rougemont, Raouf Fetni, Monique Fabre, Stefan Michiels, Gilles Vassal, Mona Beaunoyer, Michel Duval, M. Castaing
Publikováno v:
Human Pathology, Vol. 42, No 11 (2011) pp. 1727-39
Neuroblastoma is a malignant pediatric tumor with poor survival. The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including apoptosis. Thioredoxin 1, an inhibitor of tumor-suppressor phosphatase and tensin h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c477b084fefee17b0cbe011943c0673b
https://doi.org/10.1016/j.humpath.2011.01.019
https://doi.org/10.1016/j.humpath.2011.01.019
Autor:
Faes, S., Dormond, O.
Publikováno v:
International Journal of Molecular Sciences, vol. 16, no. 9, pp. 21138-21152
The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular processes. An overactivation of the pathway is frequently present in human malignancies and plays a key role in cancer progression. Hence, its inhibition has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::a2ba4f73ac3e069285422009ba1d596a
https://serval.unil.ch/notice/serval:BIB_9DD28D84F6DA
https://serval.unil.ch/notice/serval:BIB_9DD28D84F6DA
Autor:
Rafael Fernandez, Nader Perroud, Eladia Ballmann, Alain Malafosse, Romano La Harpe, Félicien Karege, S. Burkhardt
Publikováno v:
Neuropsychobiology, Vol. 63, No 4 (2011) pp. 224-31
Background: Recent studies have reported alterations in protein kinase B (PKB)/Akt and in its downstream target, glycogen synthase kinase 3β, in depression and suicide. The aim of the present study was to investigate possible impairment of the upstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3436f09b9eae53b800f743f8622f4e
https://archive-ouverte.unige.ch/unige:25420
https://archive-ouverte.unige.ch/unige:25420