Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: David Mordasini, Anne Labarre, Carlos J. Alcaide-Corral, Laurent A. Decosterd, Chrismita Hegde, Ellen Neven, Mark G. MacAskill, Marc Maillard, Dany Spaggiari, Michel Burnier, David E. Newby, Geert J. Behets, Bastien Castagner, Mattias E. Ivarsson, Patrick C. D'Haese, Antonia E. Schantl, Victoria C. Beindl, Adriana Tavares, Roberto Maj, Anja Verhulst, Jean-Christophe Leroux, Olivier Phan

Publikováno v: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

Modified mRNA for BMP-2 in Combination with Biomaterials Serves as a Transcript-Activated Matrix for Effectively Inducing Osteogenic Pathways in Stem Cells

Autor: Christian Koch, Christian Plank, Carsten Rudolph, Elizabeth R. Balmayor, Martijn van Griensven, Johannes Geiger, Manish K. Aneja

Publikováno v: Stem Cells and Development, 26(1), 25-34. Mary Ann Liebert Inc.

Bone regeneration using stem cells and growth factors has disadvantages while needing to use supraphysiological growth factors concentrations. Gene therapy has been proposed as alternative, but also has limitation. Messenger RNA (mRNA)-based transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b99fee874a31717442ee1a3d0d1cb9
https://doi.org/10.1089/scd.2016.0171

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Autor: Riccardo Ferro, Andrew M. Riley, Marco Falasca, Alessandro Fantin, Véronique Calleja, Banafshé Larijani, Barry V. L. Potter, Claudio Raimondi, Tania Maffucci, Caroline H. Brennan

Publikováno v: Scientific Reports
Raimondi, C, Calleja, V, Ferro, R, Fantin, A, Riley, A M, Potter, B V L, Brennan, C H, Maffucci, T, Larijani, B & Falasca, M 2016, ' A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion ', Scientific Reports, vol. 6, 26142 . https://doi.org/10.1038/srep26142

Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b12ef295471606085699b3eb159939
https://pubmed.ncbi.nlm.nih.gov/27199173

The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis

Autor: David Secco, Hatem Rouached, Bulak A. Arpat, Yves Poirier

Publikováno v: BMC Plant Biology, vol. 11, pp. 19
BMC Plant Biology, Vol 11, Iss 1, p 19 (2011)
BMC Plant Biology

Background Sulfate and phosphate are both vital macronutrients required for plant growth and development. Despite evidence for interaction between sulfate and phosphate homeostasis, no transcriptional factor has yet been identified in higher plants t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44c8f831595a7e04200c1b76bbf1e4a
https://doi.org/10.1186/1471-2229-11-19

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

Autor: Peter J. Cullen, Yoann Maréchal, Valérie Pouillon, Christophe Erneux, Hongbo R. Luo, Yonghui Jia, Shozo Izui, Xavier Pesesse, Julien Daniel, David Perez-Morga, Stéphane Schurmans, Oberdan Leo

Publikováno v: Proceedings of the National Academy of Sciences, Vol. 104, No 35 (2007) pp. 13978-13983

The contribution of the B isoform of inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ] 3-kinase (or Itpkb) and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5) P 4 ], its reaction product, to B cell function and development remains unknown. Here, we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f71d79b46dd4034f6ab88e39cdc9c1
https://archive-ouverte.unige.ch/unige:11441