Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: David Mordasini, Anne Labarre, Carlos J. Alcaide-Corral, Laurent A. Decosterd, Chrismita Hegde, Ellen Neven, Mark G. MacAskill, Marc Maillard, Dany Spaggiari, Michel Burnier, David E. Newby, Geert J. Behets, Bastien Castagner, Mattias E. Ivarsson, Patrick C. D'Haese, Antonia E. Schantl, Victoria C. Beindl, Adriana Tavares, Roberto Maj, Anja Verhulst, Jean-Christophe Leroux, Olivier Phan

Publikováno v: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

A Bis-calix[4]pyrrole Enzyme Mimic That Constrains Two Oxoanions in Close Proximity

Autor: Steffen Bähring, Michael Kelliher, Jonathan L. Sessler, Vincent M. Lynch, Qing He

Publikováno v: He, Q, Kelliher, M, Bähring, S, Lynch, V M & Sessler, J 2017, ' A Bis-Calix[4]pyrrole Enzyme Mimic that Constrains Two Oxoanions in Close Proximity ', Journal of the American Chemical Society, vol. 139, no. 21, pp. 7140–7143 . https://doi.org/10.1021/jacs.7b02329

Herein we describe a large capsule-like bis-calix[4]pyrrole 1, which is able to host concurrently two dihydrogen phosphate anions within a relatively large internal cavity. Evidence for the concurrent, dual recognition of the encapsulated anions came

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62fb92231a3b3fb581b2e098fa15f9e
https://doi.org/10.1021/jacs.7b02329

Development, Characterization and In Vitro Biological Properties of Scaffolds Fabricated From Calcium Phosphate Nanoparticles

Autor: Lizette Morejón, José Angel Delgado, Alexandre Antunes Ribeiro, Marize Varella de Oliveira, Eduardo Mendizábal, Ibrahim García, Adrián Alfonso, Patrina Poh, Martijn van Griensven, Elizabeth R. Balmayor

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 7
International journal of molecular sciences, 20(7):1790. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1790 (2019)

Ceramic materials mimic the mineral composition of native bone and feature osteoconductive properties
they are therefore used to regenerate bone tissue. Much research focuses on increasing the porosity and pore interconnectivity of ceramic scaff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::faef51626ef63947c8e1c3060aafc8bb

A Growth Factor-Free Co-Culture System of Osteoblasts and Peripheral Blood Mononuclear Cells for the Evaluation of the Osteogenesis Potential of Melt-Electrowritten Polycaprolactone Scaffolds

Autor: Andreas Hammerl, Carlos E. Diaz Cano, Elena M. De-Juan-Pardo, Martijn van Griensven, Patrina S.P. Poh

Publikováno v: International journal of molecular sciences, 20(5):1068. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 20
Issue 5
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1068 (2019)

Scaffolds made of biodegradable biomaterials are widely used to guide bone regeneration. Commonly, in vitro assessment of scaffolds&rsquo
osteogenesis potential has been performed predominantly in monoculture settings. Hence, this study evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3114907762db3d9b96e251572258396e
https://cris.maastrichtuniversity.nl/en/publications/49108e6f-038a-401a-9e98-e3e967ff061b

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Autor: Muzna Sadia, Waqar Ahmed, Agata Sośnicka, Mohamed Albed Alhnan, Basel Arafat, Antonios Kelarakis, Abdullah Isreb

Publikováno v: Sadia, M, Sośnicka, A, Arafat, B, Isreb, A, Ahmed, W, Kelarakis, A & Alhnan, M A 2016, ' Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets ', INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 513, no. 1-2, pp. 659-668 . https://doi.org/10.1016/j.ijpharm.2016.09.050

This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with several model drugs. It investigates the addition of non-melting filler to methacrylic matrix to facilitate FDM 3D printing and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7f2fa840e18a47c9798ef5866ded53
https://doi.org/10.1016/j.ijpharm.2016.09.050