The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.

Autor: Li Z; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Jiao X; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Robertson AG; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, VSZ 4S6, Canada.; Dxige Research, Courtenay, BC, V9N 1C2, Canada., Di Sante G; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Ashton AW; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA.; Lankenau Institute for Medical Research, 100 East Lancaster Avenue, Wynnewood, PA, 19096, USA.; Division of Perinatal Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia.; Sydney Medical School Northern, University of Sydney, Sydney, NSW, 2006, Australia., DiRocco A; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Wang M; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Zhao J; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Addya S; Department of Cancer Biology, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, PA, 19107, USA., Wang C; Department of Cancer Biology, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, PA, 19107, USA., McCue PA; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, PA, 19107, USA., South AP; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, PA, 19107, USA., Cordon-Cardo C; Department of Pathology, Mt. Sinai, Hospital, 1468 Madison Ave., Floor 15, New York, NY, 10029, USA., Liu R; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Patel K; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Hamid R; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., Parmar J; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA., DuHadaway JB; Lankenau Institute for Medical Research, 100 East Lancaster Avenue, Wynnewood, PA, 19096, USA., Jones SJM; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, VSZ 4S6, Canada., Casimiro MC; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA.; Abraham Baldwin Agricultural College, Department of Science and Mathematics, Box 15, 2802 Moore Highway, Tifton, GA, 31794, USA., Schultz N; Human Oncology and Pathogenesis Program, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kossenkov A; Center for Systems and Computational Biology, The Wistar Institute, 3601 Spruce St., Philadelphia, PA, 19104, USA., Phoon LY; Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA., Chen H; Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA., Lan L; Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA., Sun Y; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA., Iczkowski KA; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA., Rui H; Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA., Pestell RG; Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA, 18902, USA. Richard.Pestell@bblumberg.org.; The Wistar Cancer Center, Philadelphia, PA, 19104, USA. Richard.Pestell@bblumberg.org.

Publikováno v: Oncogene [Oncogene] 2023 Jun; Vol. 42 (22), pp. 1857-1873. Date of Electronic Publication: 2023 Apr 24.