Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Phong Lu"'
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 159 (2023)
It has been well established that mutations in the tumor suppressor gene, p53, occur readily in a vast majority of cancer tumors, including ovarian cancer. Typically diagnosed in stages three or four, ovarian cancer is the fifth leading cause of deat
Externí odkaz:
https://doaj.org/article/b0e81566eb114ac2bbe034a3643c8b72
Autor:
Phong Lu, Erica R. Vander Mause, Katherine E. Redd Bowman, Sarah M. Brown, Lisa Ahne, Carol S. Lim
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We have previously shown th
Externí odkaz:
https://doaj.org/article/e574237f9a1a49be9f68fcc996710ae1
Autor:
Katherine E. Redd Bowman, Lisa Ahne, Liam O’Brien, Erica R. Vander Mause, Phong Lu, Bryce Wallis, Kimberley J. Evason, Carol S. Lim
Publikováno v:
Molecular Pharmaceutics. 20:331-340
With few curative treatments and a global yearly death rate of over 800,000, hepatocellular carcinoma (HCC) desperately needs new therapies. Although wild-type p53 gene therapy has been shown to be safe in HCC patients, it has not shown enough effica
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Therapeutic Delivery. 11:833-850
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death globally, mainly due to lack of effective treatments – a problem that gene therapy is poised to solve. Successful gene therapy requires safe and efficient delivery vector
Autor:
Sarah M. Brown, Erica R. Vander Mause, Carol S. Lim, Katherine E Redd Bowman, Madeline Joklik-Mcleod, Phong Lu, Han T N Nguyen
Publikováno v:
Molecular Pharmaceutics. 16:3386-3398
Clinical trials involving p53 gene therapy for ovarian cancer failed due to the dominant negative inhibition of wild-type p53 and multiple genetic aberrations in ovarian cancer. To overcome this problem, we have designed a more potent chimeric gene f
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 240
Mitochondria are organelles that have pivotal functions in producing the energy necessary for life and executing the cell death pathway. Targeting drugs and macromolecules to the mitochondria may provide an effective means of inducing cell death for
Autor:
Phong Lu, Redd Bowman, Katherine E., Brown, Sarah M., Joklik-Mcleod, Madeline, Vander Mause, Erica R., Nguyen, Han T. N., Lim, Carol S.
Publikováno v:
Molecular Pharmaceutics; 8/5/2019, Vol. 16 Issue 8, p3386-3398, 13p
Autor:
Carol S. Lim, Phong Lu
Publikováno v:
Cancer Research. 76:3500-3500
Although the main function of p53 is a nuclear transcription factor that has important roles in cell cycle arrest, DNA repair, and apoptosis, p53 can directly trigger the intrinsic apoptotic pathway through the mitochondria. p53 has been known to bin
Autor:
Phong Lu
Publikováno v:
Cancer Research. 75:2927-2927
Although the main function of p53 is a nuclear transcription factor that has important roles in cell cycle arrest, DNA repair, and apoptosis, p53 can directly trigger the intrinsic apoptotic pathway through the mitochondria. p53 has been known to bin