Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.

Autor: Huang HH; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Ferguson ID; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Thornton AM; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA., Bastola P; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Lam C; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Lin YT; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Choudhry P; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Mariano MC; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Marcoulis MD; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Teo CF; Department of Physiology, University of California, San Francisco, CA, USA., Malato J; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Phojanakong PJ; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Martin TG 3rd; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Wolf JL; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Wong SW; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Shah N; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Brooks AN; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA., Wiita AP; Department of Laboratory Medicine, University of California, San Francisco, CA, USA. Arun.wiita@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. Arun.wiita@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Apr 22; Vol. 11 (1), pp. 1931. Date of Electronic Publication: 2020 Apr 22.