Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.

Autor: Huang HH; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Ferguson ID; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Thornton AM; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA., Bastola P; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Lam C; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Lin YT; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Choudhry P; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Mariano MC; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Marcoulis MD; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Teo CF; Department of Physiology, University of California, San Francisco, CA, USA., Malato J; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Phojanakong PJ; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Martin TG 3rd; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Wolf JL; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Wong SW; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Shah N; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Brooks AN; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA., Wiita AP; Department of Laboratory Medicine, University of California, San Francisco, CA, USA. Arun.wiita@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. Arun.wiita@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Apr 22; Vol. 11 (1), pp. 1931. Date of Electronic Publication: 2020 Apr 22.

Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.

Autor: Tseng, Chun-Che¹, Jia, Bailing^1,2, Barndt, Robert¹, Gu, Yayun¹, Chen, Chien-Yu^3,4, Tseng, I-Chu¹, Su, Sheng-Fang¹, Wang, Jehng-Kang³, Johnson, Michael D.¹ johnsom@georgetown.edu, Lin, Chen-Yong¹ lincy@georgetown.edu

Publikováno v: PLoS ONE. 8/22/2017, Vol. 12 Issue 8, p1-23. 23p.

Human Cancer Cells Retain Modest Levels of Enzymatically Active Matriptase Only in Extracellular Milieu following Induction of Zymogen Activation.

Autor: Chu, Li-Ling¹, Xu, Yuan², Yang, Jie-Ru³, Hu, Yi-An³, Chang, Hsiang-Hua^2,3, Lai, Hong-Yu², Tseng, Chun-Che^2,4, Wang, Hue-Yu¹ jkwang@ndmctsgh.edu.tw, Johnson, Michael D.², Wang, Jehng-Kang⁵, Lin, Chen-Yong² lincy@georgetown.edu

Publikováno v: PLoS ONE. Mar2014, Vol. 9 Issue 3, p1-10. 10p.

Cell surface–anchored serine proteases in cancer progression and metastasis.

Autor: Martin, Carly E., List, Karin

Publikováno v: Cancer & Metastasis Reviews; Sep2019, Vol. 38 Issue 3, p357-387, 31p

Harnessing Protease Activity to Improve Cancer Care.

Autor: Dudani, Jaideep S., Warren, Andrew D., Bhatia, Sangeeta N.

Publikováno v: Annual Review of Cancer Biology; 2018, Vol. 2, p353-376, 24p