Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Phoibe Renema"'
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Akademický článek
Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study.
Autor: Phoibe Renema, Jean-Francois Pittet, Angela P Brandon, Sixto M Leal, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T Lin, K Adam Morrow, Jessica Bell, Jonathon P Audia, Diego Alvarez, Troy Stevens, Brant M Wagener
Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0298816 (2024)
BackgroundBacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data demonstrate that bacterial pneumonia and sepsis elicit the production of cytotoxi
Externí odkaz: https://doaj.org/article/7e24ba0ec0fc45c7b6da14ffbca953db
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2
Akademický článek
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection
Autor: Kierra S. Hardy, Amanda N. Tuckey, Phoibe Renema, Mita Patel, Abu-Bakr Al-Mehdi, Domenico Spadafora, Cody A. Schlumpf, Robert A. Barrington, Mikhail F. Alexeyev, Troy Stevens, Jean-Francois Pittet, Brant M. Wagener, Jon D. Simmons, Diego F. Alvarez, Jonathon P. Audia
Publikováno v: Toxins, Vol 14, Iss 2, p 152 (2022)
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phosp
Externí odkaz: https://doaj.org/article/c9f84dac36d44282a31de0221c698954
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5
Pneumonia initiates a tauopathy
Autor: Jean-Francois Pittet, Phoibe Renema, Mike T. Lin, Jessica Bell, Troy Stevens, Brant M. Wagener, Corey E. Ventetuolo, Ron Balczon, C Michael Francis, Chung-Sik Choi, Chun Zhou, Neel R. Sodha, S.B. Voth, Ji Young Lee, Anna Koloteva, Adeel Abbasi
Publikováno v: The FASEB Journal
Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8693e0cb477a7f85b5fd06ae550f862
https://pubmed.ncbi.nlm.nih.gov/34384141
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6
KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability
Autor: Mary Kash, Ji Young Lee, Anna Koloteva, Reece P. Stevens, Sunita Subedi Paudel, Phoibe Renema, Chun Zhou, Troy Stevens
Publikováno v: Am J Respir Cell Mol Biol
KD025 is a ROCK2 inhibitor currently being tested in clinical trials for the treatment of fibrotic lung diseases. The therapeutic effects of KD025 are partly due to its inhibition of profibrotic pathways and fat metabolism. However, whether KD025 aff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1edb169ac1e6c6fa34590b53bc6d1e
https://europepmc.org/articles/PMC7528923/
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9
cAMP signaling primes lung endothelial cells to activate caspase-1 during
Autor: Phoibe, Renema, Kierra S, Hardy, Nicole, Housley, Grace, Dunbar, Naga, Annamdevula, Andrea, Britain, Domenico, Spadafora, Silas, Leavesley, Thomas, Rich, Jonathon P, Audia, Diego F, Alvarez
Publikováno v: Am J Physiol Lung Cell Mol Physiol
Activation of the inflammasome-caspase-1 axis in lung endothelial cells is emerging as a novel arm of the innate immune response to pneumonia and sepsis caused by Pseudomonas aeruginosa. Increased levels of circulating autacoids are hallmarks of pneu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21b0e85f391a85ba9a82fd7fb96fe023
https://pubmed.ncbi.nlm.nih.gov/32186399
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