Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Phoebe S. Tsoi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6825 (2024)
Biomolecular condensates (BMCs) exhibit physiological and pathological relevance in biological systems. Both liquid and solid condensates play significant roles in the spatiotemporal regulation and organization of macromolecules and their biological
Externí odkaz:
https://doaj.org/article/0c9ceec11a0f4c89ae670dbd5fee6052
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3380 (2023)
Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration, disrupts cellular functions and leads to neuronal death. Mutations, posttranslational modifications, and truncations are common molecular underpinnings in the forma
Externí odkaz:
https://doaj.org/article/d24c0e6bd3ec4173b2589b985d0c5a74
Autor:
Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil, Wilhelm Salmen, Allan Chris M Ferreon, Phoebe S. Tsoi, Yi Lasanajak, David F. Smith, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Josephine C. Ferreon, B. V. Venkataram Prasad
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HB
Externí odkaz:
https://doaj.org/article/226e37b8d4144a7d953870719068de7d
Autor:
Mahdi Muhammad Moosa, Phoebe S. Tsoi, Kyoung-Jae Choi, Allan Chris M. Ferreon, Josephine C. Ferreon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3865 (2018)
Sox2 is a pioneer transcription factor that initiates cell fate reprogramming through locus-specific differential regulation. Mechanistically, it was assumed that Sox2 achieves its regulatory diversity via heterodimerization with partner transcriptio
Externí odkaz:
https://doaj.org/article/8ded5ef998e84795ae100438e21ced85
Autor:
Josephine C. Ferreon, Antrix Jain, Kyoung-Jae Choi, Phoebe S. Tsoi, Kevin R. MacKenzie, Sung Yun Jung, Allan Chris Ferreon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1360 (2018)
Neuropathological aggregates of the intrinsically disordered microtubule-associated protein Tau are hallmarks of Alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo. Rec
Externí odkaz:
https://doaj.org/article/831668b6f17a4ab484c46ee2bac4a57e
Autor:
Kyoung-Jae Choi, My Diem Quan, Chuangye Qi, Joo-Hyung Lee, Phoebe S. Tsoi, Mahla Zahabiyon, Aleksandar Bajic, Liya Hu, B. V. Venkataram Prasad, Shih-Chu Jeff Liao, Wenbo Li, Allan Chris M. Ferreon, Josephine C. Ferreon
Publikováno v:
Nature Cell Biology. 24:737-747
Human NANOG expression resets stem cells to ground-state pluripotency. Here we identify the unique features of human NANOG that relate to its dose-sensitive function as a master transcription factor. NANOG is largely disordered, with a C-terminal pri
Autor:
Josephine C. Ferreon, Phoebe S. Tsoi, Khoa M Dao, Kyoung-Jae Choi, My Diem Quan, Allan Chris M. Ferreon
Publikováno v:
Protein Sci
Membrane-less organelles and RNP granules are enriched in RNA and RNA-binding proteins containing disordered regions. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), a key regulating protein in RNA metabolism, localizes to cytoplasmic RNP granu
Autor:
Kyoung-Jae Choi, Xi Chen, Josephine C. Ferreon, Phoebe S. Tsoi, Jin Cao, Michael A. Mancini, Jongchan Kim, Oluwatoyosi Adewunmi, Feng Xiong, Jiaofang Shao, Fabio Stossi, Elena B. Kabotyanski, Na Zhao, Alexander G. Ellis, Jeffrey M. Rosen, Lucas C. Reineke, Joel R. Neilson, Joo-Hyung Lee, Wenbo Li, Julien Dubrulle, Allan Chris M. Ferreon, Hannah L. Johnson, Tuan M. Nguyen, Li Ma
Publikováno v:
Nucleic Acids Research
Transposable elements (TEs) comprise a large proportion of long non-coding RNAs (lncRNAs). Here, we employed CRISPR to delete a short interspersed nuclear element (SINE) in Malat1, a cancer-associated lncRNA, to investigate its significance in cellul
Autor:
Maureen A. Kane, Arunendra Saha Ray, Marie-Christine Daniel, William Ghann, Yewon J Pak, Lance T. Dockery, Wenjing Li, Brian Szychowski, Phoebe S. Tsoi, Peter W. Swaan
Publikováno v:
Langmuir. 35:3391-3403
The synthesis of a novel poly(propyleneimine) (PPI) dendron in gram scale as well as its use in the formation of a highly stable, dendronized gold nanoparticle (AuNP)-based drug delivery platform is described herein. The AuNP-based platform is compos
Autor:
Shih-Chu Jeff Liao, Kyoung-Jae Choi, Mahdi Muhammad Moosa, Adriana Paulucci-Holthauzen, Allan Chris M. Ferreon, Josephine C. Ferreon, Phoebe S. Tsoi
Publikováno v:
Biochemistry. 57:6822-6826
Ribonucleoprotein (RNP) condensations through liquid-liquid phase separation play vital roles in the dynamic formation-dissolution of stress granules (SGs). These condensations are, however, usually assumed to be linked to pathologic fibrillation. He