Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Phoebe McCrorie"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 571 (2022)
Historically, pre-clinical neuro-oncological drug delivery studies have exhaustively relied upon overall animal survival as an exclusive measure of efficacy. However, with no adopted methodology to both image and quantitate brain parenchyma penetrati
Externí odkaz:
https://doaj.org/article/f34ed7de76f3431c8b60fe5cb6cfd5a2
Autor:
Paula Muresan, Phoebe McCrorie, Fiona Smith, Catherine Vasey, Vincenzo Taresco, David J. Scurr, Stefanie Kern, Stuart Smith, Pavel Gershkovich, Ruman Rahman, Maria Marlow
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
Systemic drug delivery to the central nervous system (CNS) has been historically impeded by the presence of the blood brain barrier rendering many therapies inefficacious to any cancer cells residing within the brain. Therefore, local drug delivery s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d313a063094758570b84ad9e3bd2f
https://pubmed.ncbi.nlm.nih.gov/36435313
https://pubmed.ncbi.nlm.nih.gov/36435313
Autor:
Stuart Smith, Maria Marlow, Phoebe McCrorie, Catherine E. Vasey, Ruman Rahman, Cameron Alexander
Publikováno v:
Journal of Controlled Release. 328:917-931
© 2020 We review the challenges of next-generation therapeutics for both systemic and localised delivery to brain tumours and discuss how recent engineering advances may be used to enhance brain penetration of systemic delivery therapies. The unmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb61fcab4ec96bc628e8b82f97ee0c6
https://doi.org/10.1016/j.jconrel.2020.11.022
https://doi.org/10.1016/j.jconrel.2020.11.022
Autor:
Cara Moloney, Phoebe McCrorie, Chiara Bastianchich, Bernard Ucakar, Cameron Alexander, Maria Marlow, Véronique Préat, Ruman Rahman
Publikováno v:
Neuro-Oncology. 24:vii94-vii94
Local intracranial drug delivery for high-grade glioma has been developed over the last two decades with chemotherapeutic agents administered immediately adjuvant to neurosurgery to overcome poor blood brain barrier permeability. In addition to this,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78dff0a777633de38203044993d33375
https://doi.org/10.1093/neuonc/noac209.349
https://doi.org/10.1093/neuonc/noac209.349
Publikováno v:
Neuro-Oncology. 24:vii298-vii298
INTRODUCTION Childhood medulloblastoma (MB) and atypical teratoid/rhabdoid tumours (AT/RT) are malignant brain tumours occurring in the posterior fossa, for which prognoses remains particularly poor for the MB Group 3 subtype characterised by amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78bf8fa1db3813a47e9e26fd067df82
https://doi.org/10.1093/neuonc/noac209.1161
https://doi.org/10.1093/neuonc/noac209.1161
Autor:
Eduards Krumins, Maria Marlow, Vincenzo Taresco, Phoebe McCrorie, Amanda K. Pearce, Ryan R. Larder, Hien Phan, Catherine E. Vasey, Robert I. Minut, Cameron Alexander, Ruman Rahman
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 57:1801-1810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6b5234a508b911f0e3a28f9fec2561
https://doi.org/10.1002/pola.29451
https://doi.org/10.1002/pola.29451
Autor:
Philip A. Clarke, Michael W. Fay, Jatin Mistry, Phoebe McCrorie, A.A. Ritchie, Ian A. Ward, Stuart Smith, Vincenzo Taresco, Maria Marlow, Ruman Rahman, Tatiana Lovato
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 157
Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3434accf8fc9f645a365ee5521f73b
https://pubmed.ncbi.nlm.nih.gov/33068736
https://pubmed.ncbi.nlm.nih.gov/33068736
Autor:
Phoebe McCrorie, Vincenco Taresco, Zeyuan Xu, Alison Ritchie, Phillip Clarke, Maria Marlow, Ruman Rahman
Publikováno v:
Neuro Oncol
Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063de73566e5ba2a61750c588f566998
https://europepmc.org/articles/PMC6789704/
https://europepmc.org/articles/PMC6789704/
Autor:
Phoebe McCrorie, Vincenzo Taresco, Maria Marlow, Ruman Rahman, Zeyuan Xu, A.A. Ritchie, Philip A. Clarke
Publikováno v:
Neuro Oncol
Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dd99b522f6ee5f843e7a41438e59bb
https://doi.org/10.1093/neuonc/noz175.1155
https://doi.org/10.1093/neuonc/noz175.1155
Autor:
Ruman Rahman, David J. Scurr, Phoebe McCrorie, Jonathan Rowlinson, Richard Grundy, David A. Barrett, Dong-Hyun Kim, Sarah A. Smith
Publikováno v:
Neuro Oncol
Europe PubMed Central
Europe PubMed Central
BACKGROUND Conventional oral or intravenous chemotherapy distributes drugs to the whole body whereby systemic toxicity to healthy parts of the body (e.g. bone marrow failure) limits the maximum dose that can be achieved in the brain. This presents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7e96e3597643840fde27aa64c4fd87
https://doi.org/10.1093/neuonc/noz126.208
https://doi.org/10.1093/neuonc/noz126.208