Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Phoebe C. R. Parrish"'
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13965f9f552d8b88b893eeabc031c85b
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Beth A. Kozel, Michael Lugo, Phoebe C. R. Parrish, Glennis Muldoon, Barbara R. Pober, Charles J. Billington, Zoë C. Wong, Delong Liu
Publikováno v:
Am J Med Genet A
Williams–Beuren syndrome (WBS) is a multisystem disorder caused by a hemizygous deletion on 7q11.23 encompassing 26–28 genes. An estimated 2–5% of patients have “atypical” deletions, which extend in the centromeric and/or telomeric directio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f0473069140a95fe3ad28af87d0556
https://doi.org/10.1002/ajmg.a.61522
https://doi.org/10.1002/ajmg.a.61522
Autor:
Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Mol Cell
Cuella-Martin et al. (2020) and Hanna et al. (2020) showcase CRISPR base editing in large-scale pooled screens in human cells. Base editor screens discover both loss- and gain-of-function variants, enabling protein structure/function insights and cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e55fa65cfa483530bfe88af2a30fa3f
https://europepmc.org/articles/PMC9017793/
https://europepmc.org/articles/PMC9017793/
Autor:
Austin M. Gabel, Alice H. Berger, Phoebe C. R. Parrish, Robert K. Bradley, James D. Thomas, Shriya Kamlapurkar
CRISPR knockout screens have accelerated the discovery of important cancer genetic dependencies. However, traditional CRISPR-Cas9 screens are limited in their ability to assay the function of redundant or duplicated genes. Paralogs in multi-gene fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c105f54ccfe27d21e0f952c99cc3d0aa
https://doi.org/10.1101/2020.12.20.423710
https://doi.org/10.1101/2020.12.20.423710
Autor:
Phoebe C. R. Parrish, Alice H. Berger, Austin M. Gabel, Robert K. Bradley, James D. Thomas, Shriya Kamlapurkar
Publikováno v:
Cell reports
SUMMARY CRISPR screens have accelerated the discovery of important cancer vulnerabilities. However, single-gene knockout phenotypes can be masked by redundancy among related genes. Paralogs constitute two-thirds of the human protein-coding genome, so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62d87ebdf23e2e8384e65f923436f5c
https://doi.org/10.1016/j.celrep.2021.109597
https://doi.org/10.1016/j.celrep.2021.109597
Publikováno v:
Molecular Genetics & Genomic Medicine
Background Large, multigenic deletions at chromosome 7q11.23 result in a highly penetrant constellation of physical and behavioral symptoms known as Williams–Beuren syndrome (WS). Of particular interest is the unusual social‐cognitive profile evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a835fa3abe957430b5db78decd57d145
https://pubmed.ncbi.nlm.nih.gov/30008175
https://pubmed.ncbi.nlm.nih.gov/30008175