Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Phoebe C. Parrish"'
Autor:
Amanda K. Riley, Athea Vichas, Naomi T. Nkinsi, Phoebe C. Parrish, Shriya Kamlapurkar, Alice H. Berger
Publikováno v:
Cancer Research. 82:2972-2972
Standard care of lung cancer treatment has shifted away from non-specific, cytotoxic chemotherapy in favor of targeted therapies based on genetic mutations within tumors. In 2014, somatic mutations in the small GTPase RIT1 (Ras-like in all tissues) w
Autor:
Phoebe C. Parrish, James D. Thomas, Austin M. Gabel, Shriya Kamlapurkar, Robert K. Bradley, Alice H. Berger
Publikováno v:
Cancer Research. 82:2278-2278
Synthetic lethal therapies are a promising approach to expand therapeutic options for cancer patients. Since synthetic lethal therapies target tumor cells specifically, they have fewer off-target effects than oncogene targeted approaches. To identify
Publikováno v:
Cancer Research. 81:2139-2139
Genome-scale CRISPR-Cas9 screens have enabled the identification of essential genes that can serve as cancer drug targets. However, single-gene knockout screens frequently underestimate the essentiality of paralogs, ancestrally duplicated genes that
Autor:
Alice H. Berger, Athea Vichas, Shriya Kamlapurkar, Amanda Riley, Naomi T. Nkinsi, Phoebe C. Parrish
Publikováno v:
Cancer Research. 81:2269-2269
Standard care of lung cancer is moving away from chemotherapy in favor of personalized approaches based on specific mutations in each tumor. Genome-sequencing studies have identified somatic mutations in the small GTPase RIT1 (Ras-like in all tissues