Zobrazeno 1 - 10
of 390
pro vyhledávání: '"Phipps-Green A"'
Autor:
Hailemichael Z. Hishe, Sophie L. Stocker, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman, Amanda Phipps‐Green, Daniel F. B. Wright
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 422-428 (2023)
Abstract The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs)
Externí odkaz:
https://doaj.org/article/2aebadf1e0614baaab3b5062fe752885
Autor:
Moors, Jaye, Krishnan, Mohanraj, Sumpter, Nick, Takei, Riku, Bixley, Matt, Cadzow, Murray, Major, Tanya J., Phipps-Green, Amanda, Topless, Ruth, Merriman, Marilyn, Rutledge, Malcolm, Morgan, Ben, Carlson, Jenna C., Zhang, Jerry Z., Russell, Emily M., Sun, Guangyun, Cheng, Hong, Weeks, Daniel E., Naseri, Take, Reupena, Muagututi’a Sefuiva, Viali, Satupa’itea, Tuitele, John, Hawley, Nicola L., Deka, Ranjan, McGarvey, Stephen T., de Zoysa, Janak, Murphy, Rinki, Dalbeth, Nicola, Stamp, Lisa, Taumoepeau, Mele, King, Frances, Wilcox, Phillip, Rapana, Nuku, McCormick, Sally, Minster, Ryan L., Merriman, Tony R., Leask, Megan
Publikováno v:
In Human Genetics and Genomics Advances 13 July 2023 4(3)
Autor:
Jaye Moors, Mohanraj Krishnan, Nick Sumpter, Riku Takei, Matt Bixley, Murray Cadzow, Tanya J. Major, Amanda Phipps-Green, Ruth Topless, Marilyn Merriman, Malcolm Rutledge, Ben Morgan, Jenna C. Carlson, Jerry Z. Zhang, Emily M. Russell, Guangyun Sun, Hong Cheng, Daniel E. Weeks, Take Naseri, Muagututi’a Sefuiva Reupena, Satupa’itea Viali, John Tuitele, Nicola L. Hawley, Ranjan Deka, Stephen T. McGarvey, Janak de Zoysa, Rinki Murphy, Nicola Dalbeth, Lisa Stamp, Mele Taumoepeau, Frances King, Phillip Wilcox, Nuku Rapana, Sally McCormick, Ryan L. Minster, Tony R. Merriman, Megan Leask
Publikováno v:
HGG Advances, Vol 4, Iss 3, Pp 100204- (2023)
Summary: Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic determinants of health and disease between populations, as well as furthering genomic
Externí odkaz:
https://doaj.org/article/7af5bffb2a1a41c9a4a3264dd197c255
Autor:
Anne-Katrin Emde, Amanda Phipps-Green, Murray Cadzow, C. Scott Gallagher, Tanya J. Major, Marilyn E. Merriman, Ruth K. Topless, Riku Takei, Nicola Dalbeth, Rinki Murphy, Lisa K. Stamp, Janak de Zoysa, Philip L. Wilcox, Keolu Fox, Kaja A. Wasik, Tony R. Merriman, Stephane E. Castel
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Historically, geneticists have relied on genotyping arrays and imputation to study human genetic variation. However, an underrepresentation of diverse populations has resulted in arrays that poorly capture global genetic variation
Externí odkaz:
https://doaj.org/article/295efebb8290477c8a164ca0f7d5bfec
Akademický článek
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Autor:
Philip C. Robinson, Christopher Frampton, Amanda Phipps-Green, Tuhina Neogi, Lisa Stamp, William Taylor, Tony R. Merriman, Nicola Dalbeth
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract Introduction Elevated serum urate (SU) concentration is the central risk factor for the development of gout. The aim of this study was to examine the incidence of gout in people with low and normal SU levels ( 7.00 mg/dL was 12.2%. In an adj
Externí odkaz:
https://doaj.org/article/902e9ab999264dc0bc7a8dbce65000b5
Autor:
M. Badii, O. I. Gaal, M. C. Cleophas, V. Klück, R. Davar, E. Habibi, S. T. Keating, B. Novakovic, M. M. Helsen, N. Dalbeth, L. K. Stamp, D. Macartney-Coxson, A. J. Phipps-Green, H. G. Stunnenberg, C. A. Dinarello, T. R. Merriman, M. G. Netea, T. O. Crişan, L. A. B. Joosten
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Objectives Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic processes associated to
Externí odkaz:
https://doaj.org/article/671704b4770745959533a3055de23ad9
Autor:
Ruth K. Topless, Amanda Phipps‐Green, Megan Leask, Nicola Dalbeth, Lisa K. Stamp, Philip C. Robinson, Tony R. Merriman
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 5, Pp 333-340 (2021)
Objectives The objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID‐19) diagnosis and to assess whether gout and/or RA are risk factors for death from COVID‐19
Externí odkaz:
https://doaj.org/article/29bf3bc0e3b44887b2c06327da9b1aae
Autor:
Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant r
Externí odkaz:
https://doaj.org/article/12c73f6333324432b9f2c84850631506
Autor:
Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Background The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABC
Externí odkaz:
https://doaj.org/article/88e69affacaf42ba8bbee5b52156c6c7