Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Philomena Mburu"'
Autor:
Carlos Aguilar, Debbie Williams, Ramakrishna Kurapati, Rasneer S. Bains, Philomena Mburu, Andy Parker, Jackie Williams, Danilo Concas, Hilda Tateossian, Andrew R. Haynes, Gareth Banks, Pratik Vikhe, Ines Heise, Marie Hutchison, Gemma Atkins, Simon Gillard, Becky Starbuck, Simona Oliveri, Andrew Blake, Siddharth Sethi, Saumya Kumar, Tanaya Bardhan, Jing-Yi Jeng, Stuart L. Johnson, Lara F. Corns, Walter Marcotti, Michelle Simon, Sara Wells, Paul K. Potter, Heena V. Lad
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110170- (2024)
Summary: Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behavior has not been investigated or broadly characterized. A single nucleotide variant was identified from our rece
Externí odkaz:
https://doaj.org/article/8421d27753b841d7bc0fb0382fdbd3c7
Autor:
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy. Here we show th
Externí odkaz:
https://doaj.org/article/4d4b476ec059431cbb9a7a4c796377b7
Autor:
Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp 1-23 (2019)
Abstract Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive
Externí odkaz:
https://doaj.org/article/aa32f3d7e38046868ba58a51eb9e8d12
Autor:
Jennifer Olt, Philomena Mburu, Stuart L Johnson, Andy Parker, Stephanie Kuhn, Mike Bowl, Walter Marcotti, Steve D M Brown
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87331 (2014)
Sound transduction depends upon mechanosensitive channels localized on the hair-like bundles that project from the apical surface of cochlear hair cells. Hair bundles show a stair-case structure composed of rows of stereocilia, and each stereocilium
Externí odkaz:
https://doaj.org/article/18393930fade44d8ab1ae0511d004ddf
Autor:
Philomena Mburu, María Rosario Romero, Helen Hilton, Andrew Parker, Stuart Townsend, Yoshiaki Kikkawa, Steve D M Brown
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11627 (2010)
A complex of proteins scaffolded by the PDZ protein, whirlin, reside at the stereocilia tip and are critical for stereocilia development and elongation. We have shown that in outer hair cells (OHCs) whirlin is part of a larger complex involving the M
Externí odkaz:
https://doaj.org/article/8b684e3814bb4e2ba5caa60f61807aa3
Autor:
Aziz El-Amraoui, Stuart L. Johnson, Christine Petit, Michelle Simon, Prashanthini Jeyarajan, Lauren Chessum, Michael R. Bowl, Sherylanne Newton, Andrea Lelli, Helena Rr Wells, Frances M K Williams, Andrew Parker, Joanne Dorning, Didier Dulon, Susan Morse, Suhasini R. Gopal, Steve D.M. Brown, Sedigheh Delmaghani, Philomena Mburu, Christopher T. Esapa, Ronna Hertzano, Sara Wells, Debbie Williams, Carlos A. Aguilar, Kumar N. Alagramam, Pranav Patni, Thibault Peineau, Walter Marcotti, Laura F. Corns, Sally J. Dawson, Gemma F. Codner, Lucy A Dunbar
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
International audience; Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the soun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaae1d8c8cc8054398a9affa8ff41c6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
Publikováno v:
Current Protocols in Mouse Biology
Mice are an invaluable model organism for the study of auditory function. Even though there are differences in size and frequency response, the anatomy and physiology of the mouse and human ear are remarkably similar. In addition, the tools available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f445af93d28cf3861bc8a1bfd3169a
https://doi.org/10.1002/cpmo.10
https://doi.org/10.1002/cpmo.10
Publikováno v:
Current protocols in mouse biologyLiterature Cited. 6(3)
Mice are an invaluable model organism for the study of auditory function. Even though there are differences in size and frequency response, the anatomy and physiology of the mouse and human ear are remarkably similar. In addition, the tools available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::927229e844925680256c1f4077e7d344
https://pubmed.ncbi.nlm.nih.gov/27584554
https://pubmed.ncbi.nlm.nih.gov/27584554
Publikováno v:
Nature Reviews Genetics. 9:277-290
Mouse genetics has made crucial contributions to the understanding of the molecular mechanisms of hearing. With the help of a plethora of mouse mutants, many of the key genes that are involved in the development and functioning of the auditory system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c9a9d4a8277cfbc9aac3eb8cfd604c
https://doi.org/10.1038/nrg2309
https://doi.org/10.1038/nrg2309
Autor:
Hiromichi Yonekawa, Philomena Mburu, Yoshiaki Kikkawa, Steve D.M. Brown, Stuart Townsend, Rosario Romero
Publikováno v:
Proceedings of the National Academy of Sciences. 103:10973-10978
Hearing in mammals depends upon the proper development of actin-filled stereocilia at the hair cell surface in the inner ear. Whirlin, a PDZ domain-containing protein, is expressed at stereocilia tips and, by virtue of mutations in the whirlin gene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09185a862d6cc4fd9880e0263530eefe
https://doi.org/10.1073/pnas.0600923103
https://doi.org/10.1073/pnas.0600923103