Výsledky vyhledávání - "Phillips Y. Huang"

Lgr6 is a stem cell marker in mouse skin squamous carcinomas

Autor: Melissa Q. McCreery, Reyno Delrosario, Vincent Beuger, Christine E. Wong, Allan Balmain, Jonas Sjölund, Hio Chung Kang, Jost Seibler, Kyle D. Halliwill, Arnaud Jabouille, Atul Kumar, Phillips Y. Huang, Dennis J. Eastburn, Adam Sciambi, Eve Kandyba, Maurizio Pellegrino

Publikováno v: Nature genetics

The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ff5047531efba3c1be8665ac8c5fb6
http://europepmc.org/articles/PMC5662105

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Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer

Autor: Eve Kandyba, David A. Quigley, Jonas Sjölund, Reyno Delrosario, Di Wu, Phillips Y. Huang, Gillian L. Hirst, Kyle D. Halliwill, Atul Kumar, Christine E. Wong, Facundo G. Pelorosso, Allan Balmain

Publikováno v: Cell reports, vol 16, iss 4
Cell Reports, Vol 16, Iss 4, Pp 1153-1165 (2016)

SummaryInherited germline polymorphisms can cause gene expression levels in normal tissues to differ substantially between individuals. We present an analysis of the genetic architecture of normal adult skin from 470 genetically unique mice, demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4976453a484fce1b9290af92b7d919f
https://doi.org/10.1016/j.celrep.2016.06.061

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Inflammation and Hras signaling control epithelial–mesenchymal transition during skin tumor progression

Autor: Allan Balmain, Reyno Del Rosario, Christine E. Wong, Jennifer S. Yu, Minh D. To, Phillips Y. Huang, Kuang-Yu Jen, David A. Quigley

Publikováno v: Genes & development, vol 27, iss 6

Epithelial–mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process of tumor dissemination and metastasis. About 20%–30% of Hras mutant mouse skin carcinomas induced by chemical initiation/promotion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce253facd6ac9c8ea36c7069a4f3df50
https://doi.org/10.1101/gad.210427.112

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Modeling cutaneous squamous carcinoma development in the mouse

Autor: Phillips Y. Huang, Allan Balmain

Publikováno v: Cold Spring Harbor perspectives in medicine, vol 4, iss 9

Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in Caucasian populations and is associated with a significant risk of morbidity and mortality. The classic mouse model for studying SCC involves two-stage chemical carcinogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d7b35a0ba1e240348c687b079b5682
https://escholarship.org/uc/item/21z5j6wj

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Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins

Autor: Mark Winey, Garry Morgan, Phillips Y. Huang, Uttam Surana, Karen Crasta

Publikováno v: The EMBO journal. 25(11)

In yeast, separation of duplicated spindle pole bodies (SPBs) (centrosomes in higher eukaryotes) is an indispensable step in the assembly of mitotic spindle and is triggered by severing of the bridge that connects the sister SPBs. This process requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dfb24f6bd4145a60d2bad9cbcdace9
https://pubmed.ncbi.nlm.nih.gov/16688214

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