HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit.

Autor: Strange N; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., Luu L; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., Ong V; Faculty of Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Wee BA; Faculty of Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia.; The Roslin Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Phillips MJA; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., McCaughey L; Australian Institute for Microbiology and Infection, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Steele JR; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.; Department of Biochemistry and Molecular Biology, Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Barlow CK; Department of Biochemistry and Molecular Biology, Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Cranfield CG; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., Myers G; Australian Institute for Microbiology and Infection, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., Mazraani R; School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia., Rock C; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Timms P; Centre for Bioinnovation, University of the Sunshine Coast, Maroochydore, Queensland, Australia., Huston WM; Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.

Publikováno v: Journal of bacteriology [J Bacteriol] 2024 Apr 18; Vol. 206 (4), pp. e0037123. Date of Electronic Publication: 2024 Mar 06.

Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues.

Autor: Hwang J; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand., Strange N; School of Life Sciences, Faculty of Science, University of Technology Sydney, New South Wales, Australia., Phillips MJA; School of Life Sciences, Faculty of Science, University of Technology Sydney, New South Wales, Australia., Krause AL; Department of Microbiology and Immunology, University of Otago, Dunedin, 9054, New Zealand., Heywood A; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, 9054, New Zealand., Gamble AB; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand. Electronic address: allan.gamble@otago.ac.nz., Huston WM; School of Life Sciences, Faculty of Science, University of Technology Sydney, New South Wales, Australia. Electronic address: Wilhelmina.Huston@uts.edu.au., Tyndall JDA; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand. Electronic address: joel.tyndall@otago.ac.nz.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 15; Vol. 224, pp. 113692. Date of Electronic Publication: 2021 Jul 07.