Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Phillippa J. Carling"'
Autor:
Phillippa J. Carling, William James, Rowan Flynn, Walther Haenseler, Monika Stegmann, Jane Vowles, Heyne Lee, Sally A. Cowley, Francesca J. Nicholls, Ishta Sharma, Emma R. Haberman, Richard Wade-Martins
Publikováno v:
Stem Cell Reports
Summary The Parkinson's disease-associated gene, LRRK2, is also associated with immune disorders and infectious disease and is expressed in immune subsets. Here, we characterize a platform for interrogating the expression and function of endogenous L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea0f831386e3ee4578f3f913703b8bd
https://doi.org/10.1016/j.stemcr.2020.04.001
https://doi.org/10.1016/j.stemcr.2020.04.001
Autor:
Prabhakar Rajan, Caroline Dalgliesh, Phillippa J Carling, Thomas Buist, Chaolin Zhang, Sushma N Grellscheid, Kelly Armstrong, Jacqueline Stockley, Cedric Simillion, Luke Gaughan, Gabriela Kalna, Michael Q Zhang, Craig N Robson, Hing Y Leung, David J Elliott
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29088 (2011)
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global
Externí odkaz:
https://doaj.org/article/8837ff026e9b4d53be7ae6437b1015ed
Autor:
Ishta Sharma, Richard Wade-Martins, Phillippa J. Carling, Francesca J. Nicholls, Sally A. Cowley, William James, Rowan Flynn, Jane Vowles, Heyne Lee, Monika Stegmann
SummaryThe Parkinson’s disease-associated gene, LRRK2, is also associated with immune disorders and infectious disease, and is expressed in immune subsets. Here, we characterise a platform for interrogating the expression and function of endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f1353d7e878f7e9b17fd8cc0c1dc10
Autor:
Rosie Taylor, Chris Hastings, Wenbin Wei, Oliver Bandmann, Richard Wade-Martins, Siew L. Wong, Michele T.M. Hu, Laura Ferraiuolo, Phillippa J. Carling, Kevin Talbot, Samuel Evetts, Matthew Wyles, Rachel M Hughes, Claire Green, Aurelie Schwartzentruber, Cynthia Sandor, Winston Hide, Caleb Webber, Simeon R. Mihaylov, Heather Mortiboys, Sam Willcox, Christine Lo, Thomas Payne, Hannah Clemmens
Publikováno v:
Progress in neurobiology. 187
Mechanistic disease stratification will be crucial to develop a precision medicine approach for future disease modifying therapy in sporadic Parkinson’s disease (sPD). Mitochondrial and lysosomal dysfunction are key mechanisms in the pathogenesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe55beec793504812f5f8f4287b3c4
https://pubmed.ncbi.nlm.nih.gov/32058042
https://pubmed.ncbi.nlm.nih.gov/32058042
Autor:
Christine E. M. de Die-Smulders, David C. Samuels, Hubert J.M. Smeets, Mary Herbert, Patrick J. Lindsey, Auke B C Otten, Patrick F. Chinnery, Marion Drüsedau, Suzanne C E H Sallevelt, Phillippa J. Carling, Sabine Spierts, Joseph C F M Dreesen, Aimee D C Paulussen
Publikováno v:
Human Reproduction, 33(7), 1331-1341. Oxford University Press
STUDY QUESTION: The primary objective was to assess whether germline selection events play a role during the inheritance of pathogenic mitochondrial DNA (mtDNA) variants and to provide possible underlying mechanisms for this selection. SUMMARY ANSWER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d31383cef5d0e286207cc40994eab
https://pubmed.ncbi.nlm.nih.gov/29850888
https://pubmed.ncbi.nlm.nih.gov/29850888
Publikováno v:
Mitochondrion. 11(5)
Mutations of mitochondrial DNA (mtDNA) cause a wide array of multisystem disorders, particularly affecting organs with high energy demands. Typically only a proportion of the total mtDNA content is mutated (heteroplasmy), and high percentage levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e0523596b14cac4d34baa80ad0036b
https://pubmed.ncbi.nlm.nih.gov/21635974
https://pubmed.ncbi.nlm.nih.gov/21635974
Publikováno v:
Discovery medicine. 8(41)
Prostate cancer is the most common cancer seen in aging males in the Western world, and is a major clinical challenge in uro-oncology due to biological heterogeneity. Recent advances in molecular medicine suggest that the genetic composition of a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f88bf27b3f8acd96be4a7e1ca1bfdfa9
https://pubmed.ncbi.nlm.nih.gov/19788872
https://pubmed.ncbi.nlm.nih.gov/19788872
Autor:
Cedric Simillion, Chaolin Zhang, Kelly Armstrong, David J. Elliott, Gabriela Kalna, Craig N. Robson, Phillippa J. Carling, Caroline Dalgliesh, Jacqueline Stockley, Prabhakar Rajan, Thomas Buist, Hing Y. Leung, Michael Q. Zhang, Luke Gaughan, Sushma Nagaraja Grellscheid
Publikováno v:
PLoS ONE, 2011, Vol.6(12), pp.e29088 [Peer Reviewed Journal]
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e29088 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e29088 (2011)
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d34f8959d232f16949337072b34d48
https://doi.org/10.1371/journal.pone.0029088
https://doi.org/10.1371/journal.pone.0029088