Výsledky vyhledávání - "Phillipe Urban"

Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate

Autor: Willy Hinz, Astrid Mecky, Frank Müller, Denis Pompon, Franz Oesch, Roland Kellner, Michael Arand, Phillipe Urban

Publikováno v: Biochemical Journal. 337:37-43

Microsomal epoxide hydrolase (mEH) belongs to the superfamily of α/β-hydrolase fold enzymes. A catalytic triad in the active centre of the enzyme hydrolyses the substrate molecules in a two-step reaction via the intermediate formation of an enzyme-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b7011919530ab69338c59294f41a81c
https://doi.org/10.1042/bj3370037

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Functional characterization of eight human CYP1A2 variants: the role of cytochrome b(5)

Autor: Bernardo Brito Palma, Michel Kranendonk, Phillipe Urban, José Rueff, Marta Silva e Sousa

Publikováno v: Pharmacogenetics and Genomics
Pharmacogenetics and Genomics, Lippincott, Williams & Wilkins, 2013, 23 (2), pp.41-68. ⟨10.1097/FPC.0b013e32835c2ddf⟩
Pharmacogenetics and Genomics, 2013, 23 (2), pp.41-68. ⟨10.1097/FPC.0b013e32835c2ddf⟩

Background Interindividual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP metabolism requires two electrons, which can be donated by NADPH cytochrome P450 oxidoreductase (CYPOR) and/or cytochrome b5 (b5). Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b51441c9481c30a540d36f4be2bb0c5
https://hal.archives-ouvertes.fr/hal-01268206

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