Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Phillipe D. O'Brien"'
Autor:
Amy E. Rumora, Kai Guo, Lucy M. Hinder, Phillipe D. O’Brien, John M. Hayes, Junguk Hur, Eva L. Feldman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase worldwide, accompanying complications are also on the rise. The most prevalent complication, peripheral neuropathy (PN), is a complex process which remains incompletely
Externí odkaz:
https://doaj.org/article/34cd19f263fb4d2882d0cb3b2f2a5e4c
Autor:
Claudia Figueroa-Romero, Kai Guo, Benjamin J. Murdock, Ximena Paez-Colasante, Christine M. Bassis, Kristen A. Mikhail, Kristen D. Raue, Matthew C. Evans, Ghislaine F. Taubman, Andrew J. McDermott, Phillipe D. O'Brien, Masha G. Savelieff, Junguk Hur, Eva L. Feldman
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 2 (2020)
Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease. Genetic predisposition, epigenetic changes, aging and accumulated life-long environmental exposures are known ALS risk factors. The complex and dynamic interplay between the
Externí odkaz:
https://doaj.org/article/64f5926e40e64b40a86f4cc580bd55d1
Autor:
Phillipe D. O'Brien, Kai Guo, Stephanie A. Eid, Amy E. Rumora, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Junguk Hur, Eva L. Feldman, Annemieke Aartsma-Rus, James Dowling, Maaike van Putten
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 2 (2020)
Peripheral neuropathy (PN) is a complication of prediabetes and type 2 diabetes (T2D). Increasing evidence suggests that factors besides hyperglycaemia contribute to PN development, including dyslipidaemia. The objective of this study was to determin
Externí odkaz:
https://doaj.org/article/a851f0c85a1f46e2807311fb54f9c5f8
Autor:
Lucy M. Hinder, Phillipe D. O'Brien, John M. Hayes, Carey Backus, Andrew P. Solway, Catrina Sims-Robinson, Eva L. Feldman
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 717-725 (2017)
Patients with metabolic syndrome, which is defined as obesity, dyslipidemia, hypertension and impaired glucose tolerance (IGT), can develop the same macro- and microvascular complications as patients with type 2 diabetes, including peripheral neuropa
Externí odkaz:
https://doaj.org/article/407b69ee4b3248709c88a887471042a7
Autor:
Phillipe D. O'Brien, Lucy M. Hinder, Amy E. Rumora, John M. Hayes, Jacqueline R. Dauch, Carey Backus, Faye E. Mendelson, Eva L. Feldman
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice, 5-week-old male C57BL/6J mice were fed a high-fat diet to induce diet-induced obesity (DIO), a
Externí odkaz:
https://doaj.org/article/9b149fbcbee14aa4948c000a484b4045
Publikováno v:
Diabetes Therapy. 13:389-421
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are incretin-mimetic agents that are effective adjuncts in the treatment of diabetes. This class of medications is also associated with promoting weight loss and a low risk of hypoglycemia, and so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1490c572728142d9402c2f07466eb8a
https://doi.org/10.1007/s13300-021-01198-5
https://doi.org/10.1007/s13300-021-01198-5
Autor:
Stephanie A. Eid, Phillipe D. O’Brien, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Hongyu Zhang, Lixia Zeng, Katharina Kretzler, Samanthi Narayanan, Steven F. Abcouwer, Frank C. Brosius, Subramaniam Pennathur, Masha G. Savelieff, Eva L. Feldman
Publikováno v:
Biology, Vol 9, Iss 11, p 347 (2020)
Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve, retinal, or renal damag
Externí odkaz:
https://doaj.org/article/ae980c3ab17d496ca000323a2cc2eade
Autor:
Phillipe D. O'Brien, Junguk Hur, John M. Hayes, Carey Backus, Stacey A. Sakowski, Eva L. Feldman
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 348-355 (2015)
Given the lack of treatments for diabetic neuropathy (DN), a common diabetic complication, accurate disease models are necessary. Characterization of the leptin-deficient BTBR ob/ob mouse, a type 2 diabetes model, demonstrated that the mice develop r
Externí odkaz:
https://doaj.org/article/cb593583f08240df9678cd7eaaa1e35c
Autor:
Cheng-mao Lin, Kelli M. Sas, Phillipe D. O'Brien, Eva L. Feldman, Carey Backus, John M. Hayes, Frank C. Brosius, Lucy M. Hinder, Amy E. Rumora, Pradeep P. Kayampilly, Hongyu Zhang, Steven F. Abcouwer, Sumathi Shanmugam, Subramaniam Pennathur
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients. The incidence of these complications is increasing with the diabetes epidemic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7a7c3fa6b8aeb0fc8e0aa9228f7aea
http://link.springer.com/article/10.1038/s41598-018-37376-y
http://link.springer.com/article/10.1038/s41598-018-37376-y
Autor:
Stephanie Eid, Lucy M. Hinder, Masha G. Savelieff, Phillipe D. O'Brien, Eva L. Feldman, Faye E. Mendelson, Hongyu Zhang, Samanthi Narayanan, John M. Hayes, Frank C. Brosius, Subramaniam Pennathur, Steven F. Abcouwer
Publikováno v:
Journal of translational science
Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often develop microvascular complications that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24af250179546709b576dc505a835329
https://doi.org/10.15761/jts.1000431
https://doi.org/10.15761/jts.1000431