Výsledky vyhledávání - "Phillip W. Clapp"

Akademický článek

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

Autor: Lynne T. Haber, Mark A. Bradley, Amanda N. Buerger, Holger Behrsing, Sabina Burla, Phillip W. Clapp, Scott Dotson, Casey Fisher, Keith R. Genco, Francis H. Kruszewski, Shaun D. McCullough, Kathryn E. Page, Vivek Patel, Nathan Pechacek, Clive Roper, Monita Sharma, Annie M. Jarabek

Publikováno v: Frontiers in Toxicology, Vol 6 (2024)

The use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health

Externí odkaz: https://doaj.org/article/ca72051be402475ab543842c66886536

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Vaping additives cannabinoid oil and vitamin E acetate adhere to and damage the human airway epithelium

Autor: Boris Reidel, Sabri Abdelwahab, Joe Alexander Wrennall, Phillip W. Clapp, Jessica L. Beers, Klarissa D. Jackson, Robert Tarran, Mehmet Kesimer

Publikováno v: Journal of Applied Toxicology. 43:680-693

E-cigarette, or vaping product use-associated lung injury (EVALI), is a severe respiratory disorder that caused a sudden outbreak of hospitalized young people in 2019. Using cannabis oil containing vaping products, including vitamin E acetate contami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca263c7842bf27e4941d7b7b86dfc21
https://doi.org/10.1002/jat.4415

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Respiratory Tract Deposition of E‐Cigarette Particles

Autor: William D, Bennett, Phillip W, Clapp, Landon T, Holbrook, Kirby L, Zeman

Publikováno v: Comprehensive Physiology. :3823-3832

Total and regional deposition of inhaled electronic cigarette (E-cig) particles in the respiratory tract (RT) depends on both physical properties of the inhaled particles and biological factors of users, for example, breathing pattern or puff profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c802b72eebb466ec298789b0ed03d7
https://doi.org/10.1002/cphy.c210038

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Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence

Autor: Bethany D, Batson, Bryan T, Zorn, Giorgia, Radicioni, Stephanie S, Livengood, Tadahiro, Kumagai, Hong, Dang, Agathe, Ceppe, Phillip W, Clapp, Michael, Tunney, J Stuart, Elborn, Noel G, McElvaney, Marianne S, Muhlebach, Richard C, Boucher, Michael, Tiemeyer, Matthew C, Wolfgang, Mehmet, Kesimer

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 67:253-265

The dynamics describing the vicious cycle characteristic of cystic fibrosis (CF) lung disease, initiated by stagnant mucus and perpetuated by infection and inflammation, remain unclear. Here we determine the effect of the CF airway milieu, with persi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681648006fc72052c0115e4d07fd736b
https://doi.org/10.1165/rcmb.2021-0359oc

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Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation

Autor: Beverly H. Koller, John N. Snouwaert, Adam M. Speen, Alexia Perryman, Ilona Jaspers, Jessica R. Hoffman, Hye-Young H. Kim, Ned A. Porter, William Rivera Martin, Phillip W. Clapp

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 65:500-512

Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d25dd65a10ef2bfcfb50d62e78e8930c
https://doi.org/10.1165/rcmb.2021-0032oc

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Impact of E-Cigarette Liquid Flavoring Agents on Activity of Microsomal Recombinant CYP2A6, the Primary Nicotine-Metabolizing Enzyme

Autor: Michael C. Madden, Tavleen K. Kochar, Ilona Jaspers, Brett R Winters, Phillip W. Clapp

Publikováno v: Chem Res Toxicol

Nicotine is the primary psychoactive chemical in both traditional and electronic cigarettes (e-cigarettes). Nicotine levels in both traditional cigarettes and e-cigarettes are an important concern for public health. Nicotine exposure due to e-cigaret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fb331a5f82ba538287fb187cfada86
https://doi.org/10.1021/acs.chemrestox.9b00514

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Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function

Autor: Katelyn S. Lavrich, Phillip W. Clapp, Eduardo R. Lazarowski, Ilona Jaspers, Johnny L. Carson, Catharina van Heusden

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L470-L486

Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF are unknown. The purpose of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b0017a1e69eb53392578e7f8295f15
https://doi.org/10.1152/ajplung.00304.2018

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