Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Phillip T Hawkins"'
Autor:
Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón‐Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein, Rodrigo Andres Floto
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 2, Pp 127-139 (2014)
Abstract Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement
Externí odkaz:
https://doaj.org/article/ada27d1f952241569b2948040684763a
Autor:
Karen E Anderson, Anna Kielkowska, Tom N Durrant, Veronique Juvin, Jonathan Clark, Len R Stephens, Phillip T Hawkins
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58425 (2013)
We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content. LPIAT1(-/-) mice were born at lower than Mendelian ratios and exh
Externí odkaz:
https://doaj.org/article/789b26320d9c415eae90d5bb71c19c1b
Autor:
Veronique Juvin, Mouhannad Malek, Karen E Anderson, Carine Dion, Tamara Chessa, Charlotte Lecureuil, G John Ferguson, Sabina Cosulich, Phillip T Hawkins, Len R Stephens
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75045 (2013)
We have addressed the differential roles of class I Phosphoinositide 3-kinases (PI3K) in human breast-derived MCF10a (and iso-genetic derivatives) and MDA-MB 231 and 468 cells. Class I PI3Ks are heterodimers of p110 catalytic (α, β, δ and γ) and
Externí odkaz:
https://doaj.org/article/0a3cd7d61ff64529aea09da82586974f
Autor:
Jatinder K Juss, Richard P Hayhoe, Charles E Owen, Ian Bruce, Sarah R Walmsley, Andrew S Cowburn, Suhasini Kulkarni, Keith B Boyle, Len Stephens, Phillip T Hawkins, Edwin R Chilvers, Alison M Condliffe
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45933 (2012)
We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii)
Externí odkaz:
https://doaj.org/article/b74aab3989124dae8e5cc3a0babdf320
Autor:
Marco A R Vinolo, G John Ferguson, Suhasini Kulkarni, George Damoulakis, Karen Anderson, Mohammad Bohlooly-Y, Len Stephens, Phillip T Hawkins, Rui Curi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21205 (2011)
Short chain fatty acids (SCFAs) have recently attracted attention as potential mediators of the effects of gut microbiota on intestinal inflammation. Some of these effects have been suggested to occur through the direct actions of SCFAs on the GPR43
Externí odkaz:
https://doaj.org/article/b81bd6ce141845e09edfc122af8ac149
Autor:
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to contribute to this decline. However, it remains unclear whether neutrophil responses are also impaired in old mice. Here
Externí odkaz:
https://doaj.org/article/b75bb6b2455e43bab2757f1515fb67ed
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
Autor:
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α o
Externí odkaz:
https://doaj.org/article/b4e5424c728540eebddd9be828dbc15c
Autor:
Tamara Chessa, Piotr Jung, Sabine Suire, Arqum Anwar, Karen E. Anderson, David Barneda, Anna Kielkowska, Barzan A. Sadiq, Sergio Felisbino, David Oxley, Dominik Spensberger, Anne Segonds-Pichon, Michael Wilson, Simon Walker, Hanneke Okkenhaug, Sabina Cosulich, Phillip T. Hawkins, Len R. Stephens
SummaryThe PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2-phosphatase, PTEN. Despite huge investment, the drivers of the PI3K network in normal tissues and how they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0ed33f02902073d0b4170287f0fb27d
https://doi.org/10.1101/2023.05.18.541123
https://doi.org/10.1101/2023.05.18.541123
Autor:
Aleksandra Somogyi, Emily D. Kirkham, Emyr Lloyd-Evans, Jincy Winston, Nicholas D. Allen, John J. Mackrill, Karen E. Anderson, Phillip T. Hawkins, Sian E. Gardiner, Helen Waller-Evans, Rebecca Sims, Barry Boland, Cora O'Neill
Publikováno v:
Journal of Cell Science. 136
Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these abnormalities are unclear. The transient receptor potential channel mucolipin 1(TRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7efef335499582f0e20a0cb546128e9f
https://doi.org/10.1242/jcs.259875
https://doi.org/10.1242/jcs.259875