Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Phillip R. Lazzara"'
Autor:
Katherine E. Zink, Denise A. Ludvik, Phillip R. Lazzara, Terry W. Moore, Mark J. Mandel, Laura M. Sanchez
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The complexity of animal microbiomes presents challenges to defining signaling molecules within the microbial consortium and between the microbes and the host. By focusing on the binary symbiosis between Vibrio fischeriEuprymna scolopes
Externí odkaz:
https://doaj.org/article/38dee9e7531241269427c923c2d269cd
Autor:
Phillip R. Lazzara, Terry W. Moore, Mark J. Mandel, Katherine E. Zink, Denise A. Ludvik, Laura M. Sanchez
Publikováno v:
mBio, vol 12, iss 2
mBio, Vol 12, Iss 2 (2021)
mBio
mBio, Vol 12, Iss 2 (2021)
mBio
The complexity of animal microbiomes presents challenges to defining signaling molecules within the microbial consortium and between the microbes and the host. By focusing on the binary symbiosis between Vibrio fischeri and Euprymna scolopes, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683443108b1c90ebe6ab5d1c0a61a5d7
https://escholarship.org/uc/item/1g75p5fq
https://escholarship.org/uc/item/1g75p5fq
Autor:
Denise A. Tarnowski, Terry W. Moore, Phillip R. Lazzara, Katherine E. Zink, Laura M. Sanchez, Mark J. Mandel
The lifelong relationship between the Hawaiian bobtail squid, Euprymna scolopes, and its microbial symbiont, Vibrio fischeri, represents a simplified model system for studying microbiome establishment and maintenance. The bacteria colonize a dedicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f432c860a1a20ade2d5fc370d22c7758
https://doi.org/10.1101/2020.08.17.254854
https://doi.org/10.1101/2020.08.17.254854
Autor:
Kornelia J. Skowron, Kiira Ratia, Atul D. Jain, Phillip R. Lazzara, Amanda C Maldonado, Benjamin G. Richardson, Brian P. David, Zamia Siddiqui, Terry W. Moore
Publikováno v:
ACS Med Chem Lett
[Image: see text] The oxidative stress response, gated by the protein–protein interaction of KEAP1 and NRF2, has garnered significant interest in the past decade. Misregulation in this pathway has been implicated in disease states such as multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef2827714d80a88db572e0b81460062
https://europepmc.org/articles/PMC7153276/
https://europepmc.org/articles/PMC7153276/
Autor:
Terry W. Moore, Brian P. David, Katherine Dye, Kiira Ratia, Aparna Ankireddy, Benjamin G. Richardson, Sekhar P. Reddy, Phillip R. Lazzara
Publikováno v:
J Med Chem
Pharmacological activation of NRF2 (nuclear factor erythroid 2-related factor 2) arises from blocking the interaction of NRF2 with its negative regulator, KEAP1 (Kelch-like ECH-associated protein 1). We previously reported an isoquinoline-based NRF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae73633ffe2d1957280146ae846e5a8
https://europepmc.org/articles/PMC7315935/
https://europepmc.org/articles/PMC7315935/
Autor:
Terry W. Moore, Phillip R. Lazzara
Publikováno v:
RSC Med Chem
Understanding and minimizing oxidative metabolism of aromatic compounds is a key hurdle in lead optimization. Metabolic processes not only clear compounds from the body, but they can also transform parent compounds into reactive metabolites. One part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8acbe7afec5fb5b706bbbe2dbecc69
https://pubmed.ncbi.nlm.nih.gov/33479602
https://pubmed.ncbi.nlm.nih.gov/33479602
Autor:
Terry W. Moore, Thomas E. Speltz, Simone M. Creed, Amy Lian, Changfeng Cheng, Phillip R. Lazzara, Brian P. David, Kornelia J. Skowron, Zamia Siddiqui, Kenneth Booker
Publikováno v:
Mol Cell Endocrinol
The purpose of this review is to highlight recent developments in small molecules and peptides that block the binding of coactivators to steroid receptors. These coactivator binding inhibitors bind at the coregulator binding groove, also known as Act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd2e292e5745b0b27fb444db1f45f1b
https://pubmed.ncbi.nlm.nih.gov/31163202
https://pubmed.ncbi.nlm.nih.gov/31163202
Autor:
Yue-Ting Wang, Katherine Dye, Aleksej Krunic, Haranatha R. Potteti, Chandra R. Tamatam, Kornelia J. Skowron, Benjamin G. Richardson, Phillip R. Lazzara, Atul D. Jain, Brian P. David, Terry W. Moore, Sekhar P. Reddy, Zamia Siddiqui, Ewelina Choma
Activators of Nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription factor N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f352d70d82530b721f7d392f16e5f065
https://europepmc.org/articles/PMC6190829/
https://europepmc.org/articles/PMC6190829/
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 22(47)
The synthesis of densely functionalized N-heterocycles is an ongoing challenge in chemical synthesis. Herein, we report an efficient method for the construction of pyrrolidine and piperidine scaffolds using a palladium-catalyzed carboamination of alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe174547a72fea1b9fe8a0766fae2a1
https://pubmed.ncbi.nlm.nih.gov/27661456
https://pubmed.ncbi.nlm.nih.gov/27661456
Publikováno v:
Tetrahedron Letters. 51:3969-3971
The deprotection of aromatic as well as conjugated acetals and ketals in water is catalyzed by iron(III) tosylate (1.0–5.0 mol %). Iron(III) tosylate is an inexpensive and readily available catalyst. The use of water, the most environmentally benig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de94d565b56c0bf01ff7b3e7df9a5d3d
https://doi.org/10.1016/j.tetlet.2010.05.112
https://doi.org/10.1016/j.tetlet.2010.05.112