Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Phillip Monk"'
Autor:
Tim Harrison, Karin Karlsson, Anna Malmgren, Malin Aurell, Marita Olsson, Malin Fagerås, Richard Marsden, Phillip Monk, Anders Cavallin, Christopher McCrae, Jonathan Paraskos, Carla A. Da Silva, Per Gustafson, Cecilia Wingren
Publikováno v:
Clinical and Experimental Allergy
Background Upper respiratory tract infections (URTIs) are important triggers for asthma exacerbations. We hypothesized that inhalation of the anti‐viral cytokine, interferon (IFN)‐β, during URTI, could prevent these exacerbations. Objective To e
Autor:
Pedro Mb Rodrigues, Marcin Mankowski, Salman Siddiqui, Angela Thompson, Ratko Djukanovic, Davinder Dosanjh, Najib M. Rahman, Richard J Marsden, Victoria Tear, Sandra Aitken, Toby N Batten, Jody Brookes, Alastair Watson, Tristan W Clark, Tom Wilkinson, Dave Singh, Sophie Hemmings, Lorcan McGarvey, Michael G. Crooks, Phillip Monk, Felicity J Gabbay, Stephen T. Holgate, Tim Harrison, Edmund Foster, Donna E. Davies, Adam Fleet, Ling-Pei Ho, Alex Horsley, Sarah Dudley, Dinesh Saralaya, Rona Beegan, Jacklyn A Smith
Publikováno v:
The Lancet Respiratory Medicine
Monk, P D, Marsden, R J, Tear, V J, Brookes, J, Batten, T N, Mankowski, M, Gabbay, F J, Davies, D E, Holgate, S T, Ho, L-P, Clark, T, Djukanovic, R, Wilkinson, T M A & Group, I I B COVID S 2021, ' Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial ', The Lancet. Respiratory medicine, vol. 9, no. 2, pp. 196—206 . https://doi.org/10.1016/s2213-2600(20)30511-7
Monk, P D, Marsden, R J, Tear, V J, Brookes, J, Batten, T N, Mankowski, M, Gabbay, F J, Davies, D E, Holgate, S T, Ho, L-P, Clark, T, Djukanovic, R, Wilkinson, T M A & Group, I I B COVID S 2021, ' Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial ', The Lancet. Respiratory medicine, vol. 9, no. 2, pp. 196—206 . https://doi.org/10.1016/s2213-2600(20)30511-7
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries a substantial risk of severe and prolonged illness; treatment options are currently limited. We assessed the efficacy and safety of inhaled nebulised interferon
Autor:
David E. Smart, John A. Baugh, Mark Jones, James Roberts, Donna E. Davies, Mark Ward, Phillip Monk, Katherine M.A. O'Reilly
Publikováno v:
Mechanisms of lung injury and repair.
Autor:
Mark Ward, John A. Baugh, David E. Smart, Katherine M.A. O'Reilly, Donna E. Davies, Phillip Monk, Mark Jones, James Roberts
Publikováno v:
Mechanisms of lung injury and repair.
Sarcoidosis is a multisystem disease of unknown aetiology. Up to 90% of sarcoidosis patients have lung involvement including pulmonary fibrosis. This leads to impaired quality of life and sometimes mortality. To better understand the nature of the lu
Publikováno v:
Airway pharmacology and treatment.
Background: Interferon beta (IFN-β) plays a key role in host defence against viruses, triggering the expression of interferon stimulated genes (ISG) which restrict viral replication and promote antiviral immune responses. Inhaled IFN-β is being dev
Autor:
Martin Kolb, Peter Johnson, Mark Jones, Orestis G. Andriotis, Christian H. Ottensmeier, James Roberts, Lucy Cao, Serena J Chee, Alessandra Bonfanti, Ben G. Marshall, Regan Doherty, Benjamin Johnson, David E. Smart, Donna E. Davies, Atul Bhaskar, Philipp J. Thurner, Franco Conforti, Chester Lai, Aiman Alzetani, Victoria Tear, Kjetil Ask, Wolfgang Jarolimek, Aurelie Fabre, Christopher J. Brereton, Konstantinos N. Bourdakos, Jack Gauldie, Kerry Lunn, Luca Richeldi, Katherine M.A. O'Reilly, Sumeet Mahajan, Sophie V. Fletcher, Sanjay Jogai, Patricia J. Sime, Phillip Monk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70c8ea3b0259f76bfb2ede1a0fe59a7f
https://doi.org/10.7554/elife.36354.018
https://doi.org/10.7554/elife.36354.018
Autor:
Kjetil Ask, Mark Jones, James Roberts, Victoria Tear, Kerry Lunn, Martin Kolb, James Murphy, Donna E. Davies, Lucy Cao, Jack Gauldie, Chiko Shimbori, Phillip Monk, Karun Tandon, Wolfgang Jarolimek, Jewel Imani, Ehab A. Ayaub
Publikováno v:
Mechanisms of Lung Injury and Repair.
Background: Increased tissue stiffness is a consequence and a driver of fibrosis. Tissue stiffness is modulated by the lysyl oxidase (LOX) family of enzymes, which cross-link collagen and elastin fibres. Increased expression of LOX-like-2 (LOXL2) is
Autor:
Phillip Monk, Rachel Pestridge, Jonathan Macintyre, James Roberts, Ajerico del Rosario, Chang Xiao, Sebastian L. Johnston, Rona Beegan, Peter Adura, Tatiana Kebadze, Eleanor Reed, Christine B. Boxall, James E. Gern, Victoria Cornelius, Ratko Djukanovic, Juliya Aniscenko
Publikováno v:
European Respiratory Journal
To the Editor : The majority of asthma exacerbations are associated with respiratory virus infections, mostly rhinoviruses (RVs) [1], due to enhanced inflammation in the airways [2]. These occur despite symptom control with inhaled corticosteroids (I
Autor:
Inna Vainshtein, Matthew McCourt, C Drinkwater, Trevor Wilkinson, L Roskos, C Matthews, Mark A Sleeman, Paula Harrison, Dorothy A. Sims, Meina Liang, Bo Wang, Cohen Emma S, Ralph Minter, Lutz Jermutus, G Rees, I.K. Anderson, Phillip Monk, Andrew D. Nash, Laura Eghobamien, L Fabri
Publikováno v:
British Journal of Pharmacology. 168:200-211
Background and Purpose For antibody therapies against receptor targets, in vivo outcomes can be difficult to predict because of target-mediated clearance or antigen ‘sink’ effects. The purpose of this work was to engineer an antibody to the GM-CS
Autor:
Patrick Dennison, Stephen T. Holgate, Nivenka Jayasekera, Claudia Traidl-Hoffmann, Heidrun Behrendt, Sarah Dudley, Carsten B. Schmidt-Weber, Peter H. Howarth, Cornelia Blume, Phillip Monk, Donna E. Davies, Emily J. Swindle
Publikováno v:
Eur. Respir. J. 42, 87-97 (2013)
The airway epithelium forms a physical, chemical and immunological barrier against inhaled environmental substances. In asthma, these barrier properties are thought to be abnormal. In this study, we analysed the effect of grass pollen on the physical