Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Phillip L. Casterton"'
Publikováno v:
Food and Chemical Toxicology. 68:30-37
Arruva, the R,R-isomer of monatin (sodium/potassium 2R,4R-2-amino-4-carboxy-4-hydroxy-5-(3-indolyl) pentanoate), an intense sweetener originally identified in root bark of the South African shrub Schlerochitin ilicifolius , was examined for its mutag
Autor:
Witty A. Brathwaite, J.J. Hlywka, Marisa O. Rihner, Andrey I. Nikiforov, Phillip L. Casterton, Eddie Sloter
Publikováno v:
Food and Chemical Toxicology. 62:68-75
R,R-Monatin is an intensely sweet substance originally identified in the root bark of Sclerochiton ilicifolius. R,R-Monatin salt, commonly known as "arruva", has potential for use as a high-potency sweetener food ingredient. Previously, arruva was co
Publikováno v:
Food & Function, 3(4), 410-413. Royal Society of Chemistry
The measurement of hydrogen in exhaled breath is widely accepted as a non-invasive yet efficient means to evaluate carbohydrate malabsorption. Hydrogen is not normally produced by mammalian cells and its appearance in breath indicates incomplete smal
Autor:
Marisa O. Rihner, Andrey I. Nikiforov, Witty A. Brathwaite, Eddie Sloter, Phillip L. Casterton, Stephen B. Harris, Christine M. Crincoli
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 91
(2R,4R)-Monatin salt [sodium/potassium 2R,4R-2-amino-4-carboxy-4-hydroxy-5-(3-indolyl) pentanoate] was fed at 5000, 15,000, or 35,000 ppm to Crl:CD(SD) rats over two generations. Reduced body weights were observed at all dose levels. Sustained effect
Autor:
Ralph Gingell, Francis H. Kruszewski, Neil K. Snyder, Fred A. Heitfeld, Michael K. Robinson, Mark E. Blazka, Phillip L. Casterton, Jenan Al-Atrash, David Mallon, Judith E. Swanson
Publikováno v:
Food and Chemical Toxicology. 43:1703-1712
Predictive skin irritation test methods, which do not require use of animals, are needed for the pre-market assessment of detergent formulations. The utility of a novel and ethical human acute skin irritation patch test method, originally developed f
Publikováno v:
Toxicology in Vitro. 16:621-628
The bovine cornea opacity and permeability assay (BCOP) has been in use for nearly 10 years but has not been submitted for regulatory approval. In previous reports we have presented corneal hydration and endothelial damage as additional endpoints in
Autor:
Witty A. Brathwaite, Christine M. Crincoli, Andrey I. Nikiforov, Jennifer A. Thomas, Marisa O. Rihner, Phillip L. Casterton
Publikováno v:
International journal of toxicology. 33(3)
[14C]-Labeled arruva [sodium/potassium (2R,4R)-2-amino-4-carboxy-4-hydroxy-5-(3-indolyl) pentanoate] was administered as a single gavage dose (10 mg/kg bw) to male and female Beagle dogs and 1 bile duct-cannulated male. The mean peak arruva plasma co
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 18:359-374
Ten nonionic surfactants, including five alcohol ethoxylates, were selected to test for correlations between measured eye irritation potential of surfactant solutions and a comprehensive set of surface tension measurements on the same solutions. The
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 17:197-220
The bovine corneal opacity and permeability (BCOP) assay has been proposed an an in vitro method for predicting the irritancy or toxicity of chemical substances. A loss of corneal transparency, which reduces visual acuity, can be the result of an inc
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 15:147-163
The bovine corneal opacity and permeability assay (BCOP) as originally described by Gautheron is now utilized by several laboratories to assess the eye irritation potential of individual chemicals, chemical blends, and consumer formulations. We have