Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Phillip Jobling"'
Autor:
Kateleen E Hedley, Henry M Gomez, Eda Kecelioglu, Olivia R Carroll, Phillip Jobling, Jay C Horvat, Melissa A Tadros
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phase infections are known to cause wide-spread peripheral inflammation. However, the inflammatory consequences to the crit
Externí odkaz:
https://doaj.org/article/a49dc647e187472681dad0a0129e536a
Autor:
Aysha Ferdoushi, Nathan Griffin, Mark Marsland, Xiaoyue Xu, Sam Faulkner, Fangfang Gao, Hui Liu, Simon J. King, James W. Denham, Dirk F. van Helden, Phillip Jobling, Chen Chen Jiang, Hubert Hondermarck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Pancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however
Externí odkaz:
https://doaj.org/article/57ebd719b81a48ceb0a7183729c7fd08
Autor:
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 7, Pp 398-408 (2020)
Abstract Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF
Externí odkaz:
https://doaj.org/article/c993e07b2b364f0ea4cb27aaf9d18bbb
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009912 (2022)
Accurate quantification of nerves in cancer specimens is important to understand cancer behaviour. Typically, nerves are manually detected and counted in digitised images of thin tissue sections from excised tumours using immunohistochemistry. Howeve
Externí odkaz:
https://doaj.org/article/d27e67fd5de44a8894ac893641dd6d04
Autor:
Aysha Ferdoushi, Xiang Li, Nathan Griffin, Sam Faulkner, M. Fairuz B. Jamaluddin, Fangfang Gao, Chen Chen Jiang, Dirk F. van Helden, Pradeep S. Tanwar, Phillip Jobling, Hubert Hondermarck
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Schwann cells (SCs), the glial component of peripheral nerves, have been identified as promoters of pancreatic cancer (PC) progression, but the molecular mechanisms are unclear. In the present study, we aimed to identify proteins released by SCs that
Externí odkaz:
https://doaj.org/article/30132879c8494f26b73f9fe2ec5dc843
Autor:
Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Tyler J. Browne, Robert J. Callister, Douglas W. Smith, Phillip Jobling, David I. Hughes, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures. To date, diffi
Externí odkaz:
https://doaj.org/article/bede2859bc2b436ba560bb1b689f3474
Autor:
Juliana N. Carreiro, Marciane Magnani, Phillip Jobling, Dirk F. van Helden, Eugene Nalivaiko, Valdir A. Braga
Publikováno v:
Journal of Functional Foods, Vol 33, Iss , Pp 307-313 (2017)
This study assessed the effects of resveratrol, a polyphenol found in grapes and red wine on non-pregnant murine uteri under hypoxia. Resveratrol at 1, 3, 10, 30 and 100 μM promoted uterine relaxation and decreased the amplitude and frequency of spo
Externí odkaz:
https://doaj.org/article/8002219b434a41d3abf4f37ac24c43b3
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Publikováno v:
eLife, Vol 8 (2019)
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pa
Externí odkaz:
https://doaj.org/article/e0cd9725113d49e9aa0bf5e1f78d7155
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111307 (2014)
The pacemaker mechanisms activating phasic contractions of vaginal and cervical smooth muscle remain poorly understood. Here, we investigate properties of pacemaking in vaginal and cervical tissues by determining whether: 1) functional pacemaking is
Externí odkaz:
https://doaj.org/article/462780898f4745e59f7af8d5a26ddb2a
Autor:
Mark Marsland, Amiee Dowdell, Sam Faulkner, Phillip Jobling, Robert A. Rush, Craig Gedye, James Lynam, Cassandra P. Griffin, Mark Baker, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1616
Glioblastoma multiforme (GBM) is the most lethal adult brain cancer. Temozolomide (TMZ), the standard chemotherapeutic drug used in GBM, has limited benefit and alternate therapies are needed to improve GBM treatment. Nerve growth factor (NGF) and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccca6be8495ccad3a00ae20206a3e638