Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Phillip J. Stone"'
Autor:
Stephanie E Seidl, Lawrence G Pessolano, Christopher A Bishop, Michael Best, Celeste B Rich, Phillip J Stone, Barbara M Schreiber
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0171711 (2017)
Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix component
Externí odkaz:
https://doaj.org/article/46a99d12b82f4399af967fb165e45ee6
Autor:
Jean D. Sipe, Lawrence G. Pessolano, Phillip J. Stone, Stephanie E. Seidl, Celeste B. Rich, Laura Liscum, Christopher P. Sullivan, Barbara M. Schreiber
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:2741-2750
Objective— Intracellular cholesterol distribution impacts cell function; however, processes influencing endogenous cholesterol trafficking remain largely unknown. Atherosclerosis is associated with vascular inflammation and these studies address th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70280056130d108523d56aa353054621
https://doi.org/10.1161/atvbaha.112.300243
https://doi.org/10.1161/atvbaha.112.300243
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10661-10666
Two million Americans suffer from pulmonary emphysema, costing $2.5 billion/year and contributing to 100,000 deaths/year. Emphysema is thought to result from an imbalance between elastase and endogenous inhibitors of elastase, leading to tissue destr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad195bea674659178f9d1a0443f0d1d
https://doi.org/10.1073/pnas.1001349107
https://doi.org/10.1073/pnas.1001349107
Publikováno v:
Toxicology. 267:60-69
Cadmium (Cd) inhalation can result in emphysema. Cd exposure of rat lung fibroblasts (RFL6) enhanced levels of metal scavenging thiols, e.g., metallothionein (MT) and glutathione (GSH), and the heavy chain of gamma-glutamylcysteine synthetase (gamma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878c2c3a2a236a7bccca0e0adae7267c
https://doi.org/10.1016/j.tox.2009.10.021
https://doi.org/10.1016/j.tox.2009.10.021
Publikováno v:
Biophysical Journal. 94(5):1916-1929
The goal of this study was to determine how alterations in protein composition of the extracellular matrix (ECM) affect its functional properties. To achieve this, we investigated the changes in the mechanical and failure properties of ECM sheets gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a7e2ca04ef63d231943baa4e43a438
Publikováno v:
Journal of Biological Chemistry. 282:25322-25337
Lysyl oxidase (LO) stabilizes the extracellular matrix by cross-linking collagen and elastin. To assess the transcriptional regulation of LO, we cloned the 5′-flanking region with 3,979 bp of the rat LO gene. LO transcription started at multiple si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebae47982c9482705ac74132fc2363f9
https://doi.org/10.1074/jbc.m610108200
https://doi.org/10.1074/jbc.m610108200
Autor:
Phillip J. Stone, Paul Toselli, Yinzhi Zhao, Iih-Nan Chou, Denise K. Chou, Wande Li, Song Gao
Publikováno v:
Toxicological Sciences. 99:267-276
To probe mechanisms of cadmium (Cd) damage to the lung extracellular matrix (ECM), we developed Cd-resistant (CdR) rat lung fibroblasts (RFL6) by incubation with graded concentrations of Cd. CdR cells downregulated lysyl oxidase (LO), a copper (Cu)-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb170190883fae56d9ba02329167ce71
https://doi.org/10.1093/toxsci/kfm158
https://doi.org/10.1093/toxsci/kfm158
Autor:
Paul Toselli, Sandra J. DiCamillo, Celeste B. Rich, Shenghong Yang, Estee F. Naggar, Maria V. Panchenko, Matthew A. Nugent, Mikhail P. Panchenko, Phillip J. Stone
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L232-L243
Neutrophil elastase (NE) plays an important role in emphysema, a pulmonary disease associated with excessive elastolysis and ineffective repair of interstitial elastin. Besides its direct elastolytic activity, NE releases soluble epidermal growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9644837f6cac01b839ead4f4a5192ed7
https://doi.org/10.1152/ajplung.00530.2005
https://doi.org/10.1152/ajplung.00530.2005
Publikováno v:
Biochemistry. 45:9104-9120
In the normal feedback mechanism of injury and repair in the lung, fragmented heparan sulfate proteoglycans (HSPGs) from damaged extracellular matrix and cells are believed to interact with elastases to limit their activity. An imbalance in the HSPG-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f582a6eb63de225c3922b5737144880
https://doi.org/10.1021/bi060338r
https://doi.org/10.1021/bi060338r
Publikováno v:
Toxicological Sciences. 90:478-489
Copper (Cu)-dependent lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin stabilizing the extracellular matrix (ECM). Chronic inhalation of cadmium (Cd), a toxic metal, induces emphysema. To probe mechanisms of Cd injury to the lung, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ec340d950acfcba14a76d902a71840
https://doi.org/10.1093/toxsci/kfj112
https://doi.org/10.1093/toxsci/kfj112